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Introduction to Xpreza 200mg Tablet
Xpreza 200mg Tablet is prescribed to treat adults diagnosed with Myelodysplastic syndrome (MDS) and Acute myeloid leukemia (AML) when they are deemed ineligible for stem cell transplant. Myelodysplastic Syndrome occurs when the bone marrow fails to generate healthy blood cells due to impaired function. Acute Myeloid Leukemia is characterized by the release of immature blood cells into the bloodstream, leading to bone marrow cancer.
Uses of Xpreza 200mg Tablet
- Treatment of Acute Myeloid Leukemia with 20-30% blasts in patients who are not eligible for Haemopoietic stem cell transplant
- Intermediate-2 and High-risk Myelodysplastic syndrome (MDS)
Therapeutic Effects of Xpreza 200mg Tablet
In both MDS and AML, tumor cell development is instigated by the transcriptional repression of different genes, a consequence of DNA hypermethylation. Transcriptional repression involves proteins directly or indirectly binding to DNA, regulating the process of copying specific genes or sets of genes. The active form of Xpreza 200mg Tablet interacts with RNA and DNA, disrupting their function in rapidly dividing cells, thereby exerting a toxic effect on cancerous cells.
Interaction of Xpreza 200mg Tablet with other drugs
Notify your doctor regarding any prescribed medications, over-the-counter drugs, dietary and vitamin supplements, as well as herbal products you are currently taking or have taken previously. Some medications may interact with Xpreza 200mg Tablet, potentially leading to unwanted side effects.
More Information about Xpreza 200mg Tablet
Keep at room temperature (15-30°C). Once reconstituted, the product must be used immediately. If not reconstituted, store at 2-8°C for no longer than 8 hours. Store the injection out of children’s sight and reach.
How to consume Xpreza 200mg Tablet
Only use Xpreza 200mg Tablet under the supervision of your physician. Your dose will be determined by your height, weight, and overall health condition, as directed by your physician. Xpreza 200mg Tablet is administered under the skin of your thigh, stomach, or upper arm.
Safety Advices for Xpreza 200mg Tablet
Pregnancy
Xpreza 200mg Tablet could be harmful to the unborn fetus. Inform your physician if you are pregnant or planning to get pregnant.
Breast Feeding
Breastfeeding is not intended for patients on Xpreza 200mg Tablet therapy. Consult your physician for advice.
Liver
Xpreza 200mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Xpreza 200mg Tablet may be needed. Please consult your doctor. Use of Xpreza 200mg Tablet is not recommended in patients with advanced liver cancer.
Alcohol
It is not known whether it is safe to consume alcohol with Xpreza 200mg Tablet. Please consult your doctor.
Driving
Xpreza 200mg Tablet may cause side effects which could affect your ability to drive. Xpreza 200mg Tablet can cause side effects such as tiredness and this may affect your ability to drive.
Side Effects of Xpreza 200mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious:
- Unexpected bleeding, with blood in stool and urine
- Fever
- Pneumonia, characterized by chest pain or breathlessness.
- Allergic reaction with symptoms of swelling of lips, itching or rashes.
- Seizures, loss of consciousness, severe headache or bleeding in the brain
- Frequent urination with pain or burning sensation
Common:
- Disturbances in the blood count (RBC, WBC, Platelets)
- Nausea, vomiting, diarrhea
- Constipation
- Tiredness
- Skin reaction like redness and pain at the site of injection
- Decreased appetite
- Dizziness
- Pain in extremities
- Joint pain
- Stomach pain
- Headache
- Sore nose and throat
- Rashes and bruising
Word of Advice
Prior to administration of this injection, inform the doctor of any allergic reactions, respiratory issues, kidney or liver complications, heart problems, or medications taken for other medical conditions, as they may exacerbate the situation. Refrain from using this injection if pregnancy is planned or ongoing, or if breastfeeding, as it may pose harmful effects on the developing baby. Take this injection solely under physician supervision. Doctors will determine the appropriate dosage based on the patient’s height, weight, and overall health condition. The injection is administered under the skin of the thigh, stomach, or upper arm.
FAQs
Q 1. How to use Xpreza 200mg Tablet?
Take Xpreza 200mg Tablet only under the supervision of the physician. Doctor’s will decide the dose based on patients height, weight and general condition. Xpreza 200mg Tablet is administered under the skin of your thigh, stomach or upper arm.
Q 2. Does Xpreza 200mg Tablet cause hair loss?
No, Xpreza 200mg Tablet does not cause hair loss even after using it for a prolonged period of time.
Q 3. How does Xpreza 200mg Tablet work?
Xpreza 200mg Tablet binds to RNA and DNA, interrupts their activity in actively multiplying cells and exhibits a toxic effect on cancer cells.
Fact Box of Xpreza 200mg Tablet
Molecule name: Azacitidine
Pharmacological class: Anti-Neoplastics
Therapeutic class: Anti-metabolites
Indications:
1. Treat advanced or metastatic non-small lung cancer (NSCLC), 2. To Treat Advanced or metastatic pancreatic cancer.
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