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Introduction to Adfrar 40mg Injection
Adfrar 40mg Injection contains the active ingredient Adalimumab, classified as an antirheumatic agent within the TNF (tumor necrosis factor) inhibitors medication class. It is employed either independently or in combination with other drugs to alleviate symptoms associated with certain autoimmune disorders. Adalirel is used in the treatment of rheumatoid arthritis (a condition where the body attacks its joints, resulting in pain, swelling, and loss of function) and polyarticular juvenile idiopathic arthritis (a pediatric condition characterized by the body attacking its own joints, causing pain, swelling, loss of function, and delays in growth and development).
It is also prescribed for the treatment of enthesitis-related arthritis, ankylosing spondylitis (a condition involving the body’s attack on the joints of the spine and other areas, resulting in pain and joint damage), axial spondyloarthritis without radiographic evidence of ankylosing spondylitis, psoriatic arthritis (a condition characterized by joint pain and swelling along with scales on the skin), plaque psoriasis, hidradenitis suppurativa (a skin disease causing pimple-like bumps in the armpits, groin, and anal area), Crohn’s disease, ulcerative colitis (a condition leading to swelling and sores in the lining of the colon [large intestine] and rectum), and non-infectious uveitis (swelling and inflammation in various parts of the eye).
Refrain from using Adfrar 40mg Injection if you are allergic to adalimumab or any other components in the medication. Avoid taking this medicine if you have active tuberculosis or other severe infections, as well as if you have moderate or severe heart failure. Prior to commencing the treatment, inform your physician of any active infections. Disclose to your doctor if you have pre-existing lung problems, heart diseases, or liver and kidney disorders. If you are pregnant, suspect pregnancy, or plan to conceive, seek advice from your doctor regarding the use of this medicine.
Uses of Adfrar 40mg Injection
- Rheumatoid arthritis
- Polyarticular juvenile idiopathic arthritis
- Enthesitis-related arthritis
- Ankylosing spondylitis
- Axial spondyloarthritis without radiographic evidence of ankylosing spondylitis
- Psoriatic arthritis
- Plaque psoriasis
- Hidradenitis suppurativa
- Crohn’s disease
- Ulcerative colitis
- Non-infectious uveitis
Therapeutic Effects of Adfrar 40mg Injection
The key component of this medication is a human monoclonal antibody, a type of protein that binds to a specific target. Adfrar 40mg Injection targets a protein named tumor necrosis factor (TNFα), which plays a role in the immune system and is found at elevated levels in inflammatory diseases. By binding to TNFα, Humira reduces inflammation associated with these diseases.
Interaction of Adfrar 40mg Injection with other drugs
Notify your healthcare provider of all the medications you are using, encompassing prescription drugs, over-the-counter medications, vaccines, nutritional and vitamin supplements, as well as herbal products. Some medications may interact with Adfrar 40mg Injection, diminishing its effectiveness and leading to undesirable side effects.
More Information about Adfrar 40mg Injection
- Store in a refrigerator (2°C – 8°C).
- Do not freeze.
- Protect the medicine from light and excessive moisture.
- Keep the medicine out of reach of children and pets
How to consume Adfrar 40mg Injection
Your doctor will determine the appropriate dose, duration, and frequency of administration based on your specific disease condition, severity, and other relevant factors. Adhere to the instructions provided by your doctor or pharmacist diligently. If you have any uncertainties, consult with your doctor or pharmacist for clarification.
The administration of this medicine involves subcutaneous injection, to be performed by a healthcare professional or your doctor. Refrain from self-administering this injection until you have received proper training. The dosage, duration, and frequency of administration will be determined by your doctor, taking into consideration your disease condition, severity, and other contributing factors.
Safety Advices for Adfrar 40mg Injection
Pregnancy
Avoid using Adfrar 40mg Injection during pregnancy unless advised by your doctor. Notify your physician if you are pregnant, suspect a pregnancy, or plan to conceive while undergoing treatment. It is recommended to employ effective contraception throughout the treatment period and for at least 5 months after the last dose.
Breast Feeding
Adfrar 40mg Injection is suitable for use during breastfeeding. Nevertheless, notify your physician if you are currently breastfeeding.
Lungs
Exercise caution when using Adfrar 40mg Injection in individuals with lung problems. Prior to commencing the treatment, inform your physician if you have any pre-existing lung diseases.
Liver
Exercise caution when using Adfrar 40mg Injection in patients with liver problems. Inform your physician of any existing liver diseases before commencing the treatment.
Alcohol
The safety of consuming alcohol during treatment with Adfrar 40mg Injection is uncertain. Seek advice from your doctor for more guidance.
Driving
Adfrar 40mg Injection may slightly impact your ability to drive, cycle, or operate machinery. The occurrence of a spinning sensation and vision disturbances is possible after taking this medication.
Side Effects of Adfrar 40mg Injection
Side effects are undesired symptoms triggered by medications. While all drugs may induce side effects, not everyone experiences them.
Serious:
- Heart problems
- Abnormal heart beat
- Severe skin reactions
- GI bleeding
- Abnormal blood count values
- Liver injury
- Bone problems
- Infections
- Severe respiratory problems
Common:
- Injection site reactions
- Rash
- Headache
- Sinusitis
- Upper respiratory infections
- Fever
Word of Advice
Certain vaccines may pose infection risks and should be avoided while undergoing this medication; consult your doctor before receiving any vaccines. Notify your doctor if you currently have or have had a hepatitis B infection, as this medicine may elevate the risk of a recurrence. You may receive guidance on self-administering the medicine at home, so ensure you comprehend all instructions before performing an injection.
You will be instructed on suitable body areas for administering the shot. Utilize a different body area for each injection to ensure proper rotation. Keep a record of the administered shots to track rotation. Avoid injecting into areas of the skin that are red, bruised, tender, or firm. If you miss a dose, take it as soon as you remember. If the next dose is near, wait and take the regular dose. Avoid taking extra medicine to compensate for a missed dose.
FAQs
Q 1. How long does it take for Adfrar 40mg Injection to start working?
The reaction to Adfrar 40mg Injection can differ among individuals and the specific condition being treated. Some individuals may notice an improvement in symptoms within a few weeks, while others may require a longer duration. It is crucial to adhere to the instructions provided by the healthcare provider and be patient, allowing ample time for the medication to exert its effects.
Q 2. Can Adfrar 40mg Injection increase the risk of infections?
Adfrar 40mg Injection may elevate the risk of severe bacterial, viral, or fungal infections. It is crucial to promptly notify a healthcare provider of any indications of infection while undergoing this medication. Inform your physician if you have had or currently have any active infections.
Q 3. What are the common side effects of Adfrar 40mg Injection?
Frequent side effects of Adfrar 40mg Injection may involve reactions at the injection site, such as pain, redness, or swelling. Other potential side effects encompass headaches, upper respiratory infections, nausea, and rash. While serious side effects are uncommon, they can still occur.
Q 4. How long can I take Adfrar 40mg Injection?
The duration of Adfrar 40mg Injection treatment is contingent on the individual’s condition and their response to the medication. In certain instances, this medicine may serve as a long-term maintenance therapy, while in other situations, the treatment duration may be shorter. Adhering to the healthcare provider’s guidance is crucial in determining the appropriate duration of treatment.
Q 5. Can Adfrar 40mg Injection be used in individuals with kidney or liver impairment?
Dosage adjustments or careful consideration may be necessary when administering Adfrar 40mg Injection to individuals with kidney or liver impairment. Healthcare providers will evaluate the patient’s condition and determine the suitable dosage, taking into account both renal and hepatic function.
Fact Box of Adfrar 40mg Injection
Molecule name: Adalimumab
Pharmacological class: TNF inhibitors
Therapeutic class: Antirheumatic agent, Monoclonal antibody
Indications:
1. Rheumatoid arthritis
2. Polyarticular juvenile idiopathic arthritis
3. Enthesitis-related arthritis
4. Ankylosing spondylitis
5. Axial spondyloarthritis without radiographic evidence of ankylosing spondylitis
6. Psoriatic arthritis
7. Plaque psoriasis
8. Hidradenitis suppurativa
9. Crohn’s disease
10. Ulcerative colitis
11. Non-infectious uveitis
1. Rheumatoid arthritis
2. Polyarticular juvenile idiopathic arthritis
3. Enthesitis-related arthritis
4. Ankylosing spondylitis
5. Axial spondyloarthritis without radiographic evidence of ankylosing spondylitis
6. Psoriatic arthritis
7. Plaque psoriasis
8. Hidradenitis suppurativa
9. Crohn’s disease
10. Ulcerative colitis
11. Non-infectious uveitis
References
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Immunosuppressants, tolerogens, and immunostimulants, 12th edition, 2011, 1018.
- KD Tripathi, Essentials of Medical Pharmacology, Antirheumatoid and antigout drugs, 7th edition, 2013, 213.
- AbbVie Ltd, Electronic medicines compendium (emc), [ Revised on April 2021] [ Accessed on July 2023], https://www.medicines.org.uk/emc/files/pil.2150.pdf
- AbbVie Inc, US Food and Drug Administration, [ Revised on Feb 2021] [ Accessed on July 2023], https://www.rxabbvie.com/pdf/humira.pdf
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