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Introduction to Krabeva 400mg Injection
Krabeva 400mg Injection is an anticancer medication containing the active ingredient Bevacizumab, designed to inhibit tumor growth. It is prescribed in combination with other chemotherapy drugs for metastatic breast cancer, brain cancer, cervical cancer, kidney cancer, lung cancer, and colorectal cancer. It is also used for ovarian, fallopian tube, or primary peritoneal cancers.
During treatment and for at least six months afterward, effective birth control is recommended. Krabeva 400mg Injection is not suitable for adolescents and children under 18. If pregnancy is planned in the near future, discuss ovarian preservation with your doctor, as this medication may impact fertility in women. Avoid breastfeeding while using this medication, as it may affect the baby’s growth and development.
Krabeva 400mg Injection is typically administered alongside other chemotherapy medications. Common side effects include constipation, loss of appetite, runny nose, fever, skin issues, and weight loss. Before starting treatment with Krabeva 400mg Injection, inform your doctor if you have high blood pressure, high blood sugar, stomach disorders, or heart problems.
Avoid taking this medication for 28 days before and after surgery due to its association with impaired wound healing and increased risk of bleeding. Inform your doctor about any dental issues requiring surgery before starting treatment. If you experience visual changes or confusion, contact your doctor promptly to prevent potential complications.
Uses of Krabeva 400mg Injection
- Glioblastoma multiforme (brain cancer)
- Persistent, recurrent, or metastatic breast cancer
- Metastatic cervical cancer
- Advanced kidney cancer
- Metastatic colorectal cancer
- Advanced non-small-cell lung cancer
- Liver Cancer- Hepatocellular carcinoma
- Cancers of the ovary, cervical, fallopian tube, or primary peritoneal cancer
Therapeutic Effects of Krabeva 400mg Injection
Krabeva 400mg Injection is a recombinant humanized monoclonal antibody used as targeted therapy for treating several advanced cancers. It functions by selectively binding to vascular endothelial growth factor A (VEGF-A), a protein found in the lining of blood and lymph vessels. By disrupting the interaction between VEGF-A and its receptors, it inhibits the formation of blood vessels that nourish tumors with oxygen and nutrients. This mechanism effectively slows the progression of cancer.
Interaction of Krabeva 400mg Injection with other drugs
Before starting treatment, inform your doctor about all prescribed medications, over-the-counter drugs, nutritional supplements, vitamins, and herbal products you are currently taking or have taken previously. Some medications may interact with Krabeva 400mg Injection, leading to potential undesirable side effects.
More Information about Krabeva 400mg Injection
- Store Krabeva 400mg Injection at 2˚C to 8˚C. Do not freeze or shake.
- Protect from light. Keep out of reach of children.
How to consume Krabeva 400mg Injection
Your physician or nurse will administer Krabeva 400mg Injection as an intravenous infusion. The infusion should be given immediately after the dilution.
Safety Advices for Krabeva 400mg Injection
Pregnancy
Inform your physician before starting your treatment with Krabeva 400mg Injection in case, if you are pregnant or planning for pregnancy as this medicine may cause harm to the unborn baby and interrupt the formation of blood vessels.
Breast Feeding
It is recommended to avoid breastfeeding for a minimum of 6 months after your treatment with Krabeva 400mg Injection as this medicine may interfere with the growth of your child.
Liver
Inform your physician before starting Krabeva 400mg Injection if you have liver diseases to avoid any serious side effects.
Alcohol
Consult your doctor to know if it is safe to consume alcohol while you are on treatment with Krabeva 400mg Injection as only limited studies are available.
Driving
Avoid driving or using machinery while you are on your treatment with Krabeva 400mg Injection as it is related to cause dizziness or sleepiness.
Side Effects of Krabeva 400mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Serious
- Headache
- Vision changes
- Confusion
- Severe allergic reactions
- High Blood pressure
- Delayed wound healing following surgery
- Protein in urine
- Severe infections
- Blood clots in arteries and blood vessels of lungs
- Gut perforation
- Nosebleeds and bleeding risk
- Heart problems with an increase in heart rate
- Mouth sores, dryness
- Shortness of breath
Common
- Numbness in hands or feet
- Weakness and lack of energy
- Diarrhoea, nausea, vomiting, abdominal pain
- Constipation
- Loss of appetite
- Weight loss
- Changes in taste and speech
- Decrease in counts of white blood cells
- Fever
- Dry skin
- Back pain
Word of Advice
Before receiving Krabeva 400mg Injection, it is crucial to inform your physician if you:
– Have stomach conditions involving inflammation such as ulcers or colitis.
– Have experienced allergic reactions to Krabeva 400mg Injection or any of its components.
– Have undergone recent surgery, as this medication is associated with an increased risk of bleeding.
– Have diabetes, hypertension, or heart problems.
FAQs
Q 1. Is Krabeva 400mg Injection used as standalone treatment in cancers?
Krabeva 400mg Injection is a recombinant monoclonal antibody that belongs to the immunotherapy class of cancer treatment. It can either be used as monotherapy or in combination with chemotherapy or immunotherapy medications to improve the overall survival rate.
Q 2. Is it safe for women to use Krabeva 400mg Injection?
While for women with reproductive potential subjected to Krabeva 400mg Injection, it is advised to discuss with your doctor regarding the effective birth control methods during the treatment. Also to be continued for a minimum of 6 months after the treatment course completion as this medicine may impair fertility.
Q 3. Is it safe to undergo a surgery during the treatment with Krabeva 400mg Injection?
Krabeva 400mg Injection is associated with increased risk of bleeding complications and poor wound healing. Hence it is suggested to avoid planning for surgery and maintain an interval of 28days before or after surgery.
Fact Box of Krabeva 400mg Injection
Molecule name: Bevacizumab
Pharmacological class: VEGF Inhibitor
Therapeutic class: Anticancer
Indications:
1. Glioblastoma multiforme (brain cancer)
2. Persistent, recurrent, or metastatic breast cancer
3. Metastatic cervical cancer
4. Advanced kidney cancer
5. Metastatic colorectal cancer
6. Advanced non-small-cell lung cancer
7. Liver Cancer- Hepatocellular carcinoma
8. Cancers of the ovary, cervical, fallopian tube, or primary peritoneal cancer
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