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Introduction to Calcium Folinate 50mg Injection
Calcium Folinate 50mg injection is an anticancer medication classified as a detoxifying agent, with the active ingredient Calcium Folinate. It is used to treat megaloblastic anemia, a condition characterized by the presence of large, immature, and dysfunctional red blood cells (megaloblasts) in the bone marrow. Additionally, it is used to enhance the effectiveness of 5-fluorouracil in certain cancer treatments by increasing the drug’s efficacy while reducing its toxicity. This drug can also be used to treat overdoses of folic acid antagonists and helps protect healthy cells by “rescuing” them from the toxic effects of chemotherapy.
Calcium Folinate is contraindicated in patients with hypersensitivity reactions. Allergic reactions to this medication may occur, with symptoms including itching, difficulty breathing, swelling of the face or throat, and a rapid heartbeat. If any of these symptoms occur, seek medical attention immediately. It is important to avoid excessive doses of this drug, as it may diminish the antitumor activity of methotrexate, especially in CNS tumors, where the drug can accumulate after repeated treatments.
Uses of Calcium Folinate 50mg Injection
- Treatment of Megaloblastic Anaemia
- Reduce the toxicity of methotrexate
- Overdose of Folic Acid Antagonists
- Enhance the effectiveness of 5-fluorouracil
Therapeutic Effects of Calcium Folinate 50mg Injection
It is also known as folinic acid which is an essential for the production of DNA and the formation of red blood cells. When cells are rapidly dividing, as in cancer cells or in the normal cells of the bone marrow, folic acid is required for cell division. This medicine works by enhancing the effects of folic acid in the body. It is taken up by cells through a specific transporter protein and converted into the active form of folic acid, which can be used by cells to produce DNA and form new cells. This drug is given after methotrexate to help rescue normal cells that require folate for their growth.
Interaction of Calcium Folinate 50mg Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Calcium Folinate 50mg injection and reduce effectiveness by causing undesirable side effects.
More Information about Calcium Folinate 50mg Injection
- Store Calcium Folinate 50mg injection in a refrigerator(2°C-8°C).
- Protect from sunlight
- Keep it out of reach from children and pets.
How to consume Calcium Folinate 50mg Injection
The medicine will be administered to you by a healthcare professional in a hospital setting. This injection will be given slowly into a vein (as an injection or infusion) or it may be injected into a muscle. Do not self-administer this medicine. The dose of the injection will be decided by your doctor based on your disease condition and other factors.
Safety Advices
Pregnancy
It is not known whether Calcium injection can cause foetal harm, when administered to pregnant women. Consult your doctor if you are pregnant or planning for pregnancy during the treatment.
Breast Feeding
It is not known if Calcium injection passes into your breast milk or if it will affect your baby. Please consult your doctor before breastfeeding.
Lungs
It is not known whether Calcium injection can be administered to patients with lung problems. Consult your doctor if you have any lung diseases before starting the treatment.
Liver
Inform your doctor if you have any liver problems before taking injection. Regular monitoring of liver function tests is recommended.
Alcohol
It is unknown whether consuming alcohol interacts with the injection. Please consult your doctor for more advice.
Driving
It is completely safe to drive after taking the injection.
Side Effects
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious
- Reduced number of blood cells
- Inflammation in the lining of mouth and intestine
- Severe allergic reactions
Common
- Nausea, vomiting, severe diarrhoea
- Redness and swelling of palms of hands and soles of feet
Word of Advice
Special care is needed if you are elderly and you are about to receive any fluorouracil treatment and injection at the same time in case you undergo radiotherapy or stomach trouble. Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
FAQs
Q 1. What are the special precautions I should be aware of before starting treatment with Calcium Folinate 50mg injection?
This drug is eliminated from the body primarily through the kidneys. Patients with impaired kidney function may need a lower dose or less frequent dosing of Calcium Folinate 50mg injection.
Q 2. Can Calcium Folinate 50mg injection be used in combination with other drugs?
Yes, Calcium Folinate 50mg injection is used as an antidote to reduce the toxic effects of methotrexate, a chemotherapy drug that is used to treat certain types of cancer.
Q 3. What does Calcium Folinate 50mg injection do to your body?
Calcium Folinate 50mg injection works by supplying the body with the necessary folate, which is required for the production of red blood cells, DNA synthesis, and other important cellular functions.
Fact Box
Molecule name: Calcium Folinate
Pharmacological class: Detoxifying agents
Therapeutic class: Anti-cancer
Indications:
1.Treatment of Megaloblastic Anaemia
2.Reduce the toxicity of methotrexate
3.Treatment of Overdosage of Folic Acid Antagonists
4.Enhance the effectiveness of 5-fluorouracil
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