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Introduction to Alecensa 150mg Capsule
Alecensa 150mg Capsule contains the active ingredient Alectinib Hydrochloride and is employed as an anti-cancer medication for treating Non-small cell lung cancer (NSCLC), an advanced and metastatic form of lung cancer. It is effective in addressing NSCLC that has spread to other body parts, including the brain. Alecensa 150mg Capsule is generally well-tolerated with fewer side effects compared to traditional chemotherapy, potentially enhancing a person’s quality of life during treatment and enabling them to maintain their daily activities.
Before initiating treatment, inform your doctor if you are using oral contraceptives, as this medication may diminish their effectiveness. Disclose any issues with the stomach, intestine, abdomen, heart, or lung inflammation, or if you are lactose intolerant. It is crucial to apply sun protection while using Alecensa 150mg Capsule and continue for up to 7 days after discontinuation, as the medication can cause sensitivity to sunlight. Exercise caution when consuming grapefruit and Seville oranges, as they may reduce the efficacy of the medication.
Uses of Alecensa 150mg Capsule
- To treat ALK-positive lung cancer (NSCLC) that has spread to other organs.
Therapeutic Effects of Alecensa 150mg Capsule
Alecensa 150mg Capsule exerts its therapeutic effects by targeting a specific genetic mutation known as anaplastic lymphoma kinase (ALK) in non-small cell lung cancer (NSCLC) cells. Through the inhibition of the ALK protein, this medication can impede or halt the growth and dissemination of cancer cells harboring the ALK genetic mutation.
Interaction of Alecensa 150mg Capsule with other drugs
Notify your healthcare provider about all the medications you are using, including prescription drugs, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Some medications may interact with Alecensa 150mg Capsule, potentially reducing its effectiveness and leading to undesirable side effects.
More Information about Alecensa 150mg Capsule
- Alecensa 150mg Capsule should be stored at room temperature between 68°F to 77°F (20°C to 25°C).
- Keep in the original container.
- Keep away from light, moisture, and heat.
- Once opened, the blister pack should be used within 14 days.
How to consume Alecensa 150mg Capsule
Alecensa 150mg Capsule is administered orally in capsule form and should be taken with food. The capsules must be swallowed whole with water and should not be crushed, chewed, or opened. The appropriate dosage and treatment duration are individualized based on the person’s condition and response to the medication, as determined by a healthcare provider. If a dose is omitted, it should be taken promptly unless it is within 12 hours of the next scheduled dose, in which case the missed dose should be skipped. It is advised not to take double doses to compensate for a missed one.
Safety Advices for Alecensa 150mg Capsule
Pregnancy
Alecensa 150mg Capsule should not be used during pregnancy as it may pose harm to the developing baby.
Breast Feeding
The excretion of Alecensa 150mg Capsule in milk is uncertain. Therefore, it is advisable for breastfeeding mothers to consult a healthcare provider before taking this medication.
Lungs
Alecensa 150mg Capsule is considered safe for use in lung patients and can be effective in treating NSCLC. However, it is not without potential side effects. Regular monitoring of lung function is crucial during the course of treatment with this medication.
Liver
Alecensa 150mg Capsule has the potential to cause liver damage or failure in certain individuals; hence, it is crucial to monitor liver function throughout the treatment. Prior to initiating treatment, a healthcare provider will conduct blood tests to evaluate liver function.
Alcohol
Consuming alcohol can adversely affect the immune system and may interfere with the effectiveness of cancer therapies. Therefore, it is advised to refrain from alcohol intake while undergoing this treatment.
Driving
Patients taking Alecensa 150mg Capsule are cautioned against driving or operating machinery if they encounter side effects such as fatigue, dizziness, or blurred vision, as these may impair their ability to do so safely.
Side Effects of Alecensa 150mg Capsule
Similar to all medications, Alecensa 150mg Capsule has the potential to cause side effects, although not everyone taking it will necessarily experience them.
Serious:
- Yellowing of skin and white parts of the eye
- Dark urine
- Pain at the right side of the stomach
- Skin itching
- Loss of appetite
- Nausea and vomiting
- Easy bleeding or bruising
- Persistent muscle pain
- Tender or weak muscles
- Loss of consciousness
- Dizziness
- Low blood pressure
- Difficulty breathing
- Cough with or without mucous
- Fever
Common:
- Elevated liver enzymes
- Rashes
- Odema (fluid build-up causing swelling)
- Fatigue
- Diarrhea
- Constipation
- Weight gain
- Inflammation in mouth
- Light sensitivity
- Changes in taste
Word of Advice
Alecensa 150mg Capsule is a potent medication with the potential for serious side effects. Therefore, it is crucial to adhere to your healthcare provider’s instructions, promptly report any side effects or changes in your health, and inform your doctor if you are using contraceptives. For women at risk of pregnancy, effective birth control should be used during treatment and for at least three months after the last dose. Prior to taking the medication, disclose any history of stomach, intestine, abdomen, heart, or lung inflammation to your doctor. Cancer patients are advised to maintain a diet rich in fruits, vegetables, whole grains, and lean proteins while limiting processed and high-fat foods. Staying hydrated by drinking plenty of water is also recommended during cancer treatment.
FAQs
Q 1. What is ALK Positive lung cancer?
ALK-positive lung cancer represents a subgroup of lung cancer prevalent among nonsmokers under the age of 55. ALK, an acronym for anaplastic lymphoma kinase, is a protein. Mutation in this gene leads to the accelerated growth of lung cancer cells.
Q 2. Can Alecensa 150mg Capsule cause weight gain?
Although not very common, weight gain is a possible side effect of Alecensa 150mg Capsule. If you observe unexplained weight gain during its use, inform your healthcare provider.
Q 3. Can Alecensa 150mg Capsule cause mood changes or depression?
Some patients taking Alecensa 150mg Capsule have reported mood changes and depression. If you notice any alterations in your mood or experience feelings of depression while using this capsule, it is essential to inform your healthcare provider. They may suggest additional support or recommend treatment for depression.
Q 4. Is Alecensa 150mg Capsule used in patients with brain metastases?
Alecensa 150mg Capsule has demonstrated effectiveness in treating brain metastases in individuals with ALK-positive NSCLC. Its ability to penetrate the blood-brain barrier allows it to reach brain tissue, potentially aiding in the control of cancer cell growth in the brain.
Q 5. Can I use Alecensa 150mg Capsule if I have kidney problems?
Alecensa 150mg Capsule does not undergo substantial metabolism by the kidneys, making it suitable for use in patients with mild to moderate kidney issues without the need for dosage adjustment. However, individuals with severe kidney problems may necessitate dosage adjustments or additional monitoring.
Fact Box of Alecensa 150mg Capsule
Molecule name: Alectinib
Pharmacological class: Tyrosine kinase inhibitor
Therapeutic class: Anticancer
Indications: ALK-positive lung cancer (NSCLC)
References
- Roche, Electronic Medicines Compendium (EMC), [Revised on January 2022] [Accessed on 15th April 2023] https://www.medicines.org.uk/emc/files/pil.2438.pdf
- Genentech, Inc., [Revised on September 2021] [Accessed on 15th April 2023], https://www.gene.com/download/pdf/alecensa_prescribing.pdf
- Goodman & Gilman’s Pharmacological Basis of Therapeutics, 13th Edition, 2018, 1203-1236.
- Genentech , Inc.U.S FDA (Food and Drug Safety Adminitstration), [ Last Revised November 2016], [Accessed on 15th April 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208434s003lbl.pdf
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