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METFORMIN,VILDAGLIPTIN
This page provides concise information about the drug Metformin-Vildagliptin, including its indications, dosage and administration guidelines, mechanism of action, related brands and their strengths, warnings, and common side effects.
Background and Date of Approval
Metformin combined with Vildagliptin is used medically to treat type 2 diabetes mellitus and hyperglycemia. It also helps improve insulin sensitivity and aids in weight management.
Mechanism of Action of Metformin,vildagliptin
Metformin and Vildagliptin manage type 2 diabetes mellitus by combining their distinct mechanisms of action. Vildagliptin inhibits the DPP-4 enzyme, raising active incretin hormone levels to stimulate insulin secretion and reduce glucagon release. Metformin decreases hepatic glucose production, enhances peripheral glucose uptake, and improves insulin sensitivity by activating AMPK. Together, these actions help regulate blood sugar levels through complementary pathways.
AVAILABLE BRANDS
Uses of Metformin,vildagliptin
Metformin combined with Vildagliptin is primarily used to manage type 2 diabetes mellitus. It controls hyperglycemia and improves insulin sensitivity in patients with this condition.
Metformin,vildagliptin Drug administaration and Dosage available
Metformin combined with Vildagliptin is taken orally in tablet form, available in a strength of 50mg/500mg. The recommended starting dosage and any necessary adjustments are determined based on the specific condition being treated and the patient’s response to the medication.
Warnings, Precautions and Side Effects of Metformin,vildagliptin
Warnings
Lactic acidosis, a rare but potentially serious condition, can occur with the use of Metformin and Vildagliptin. Additionally, the risk of hypoglycemia increases when this combination is used alongside other antidiabetic medications.
Precautions
Seek immediate medical attention if you experience symptoms such as muscle pain, weakness, abdominal discomfort, hyperventilation, or unusual sleepiness after taking Metformin and Vildagliptin. Close monitoring of blood sugar levels is crucial, particularly during the initial phase of treatment.
Side Effects
Metformin combined with Vildagliptin may cause several side effects that vary in severity. Common side effects include gastrointestinal disturbances such as nausea, vomiting, diarrhea, and abdominal discomfort. Individuals may also experience headaches, dizziness, weakness, and a metallic taste in the mouth. More serious but rare side effects include lactic acidosis, which can be life-threatening, and severe allergic reactions characterized by rash, itching, swelling, dizziness, and breathing difficulties.
Word Of Advice
Regularly monitor kidney function as Metformin and Vildagliptin are eliminated through the kidneys. Be cautious of low blood sugar levels, especially when taking other diabetes medications. Watch for symptoms of lactic acidosis and seek immediate medical help if they occur. Temporarily stop the medication before using contrast agents for medical tests. Use with care in patients with liver problems and be mindful of any signs of infection. Inform healthcare providers about the medication before any surgery or medical procedures. Be aware of potential allergic reactions and report any promptly. Monitor for vitamin B12 deficiency during long-term use and consider supplementation if needed. Stay hydrated, especially during illness or hot weather, to prevent dehydration complications. Consult a healthcare provider for any changes in management during periods of stress, such as surgery or infections. Use caution during pregnancy and lactation, and discuss potential risks and benefits with a healthcare provider.
Disclaimer
The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.