Home > LAMIVUDINE,NEVIRAPINE,ZIDOVUDINE

About Lamivudine,nevirapine,zidovudine

This page provides concise information on the drugs lamivudine, nevirapine, and zidovudine, including their indications, dosage and administration guidelines, mechanisms of action, associated brands with their strengths, as well as warnings and common side effects.

Background and Date of Approval

The combination of Lamivudine, Nevirapine, and Zidovudine constitutes a trio of antiretroviral medications approved by the U.S. Food and Drug Administration for the treatment of HIV-1 infection.

Mechanism of Action of Lamivudine,nevirapine,zidovudine

The combination of Lamivudine, Nevirapine, and Zidovudine comprises three antiretroviral medications. Lamivudine and Zidovudine function by inhibiting the reverse transcriptase enzyme of HIV, limiting viral genome replication, and decreasing the generation of new infectious viral particles. Their primary mechanism involves interference with reverse transcription, impeding the spread of HIV. Nevirapine, on the other hand, directly binds to reverse transcriptase (RT), disrupting the enzyme and blocking both RNA-dependent and DNA-dependent polymerase activities.

AVAILABLE BRANDS

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Zidolam-N Tab
GENX PHARMA LTD ₹210.00
Duovir-N Tab
CIPLA LTD ₹633.36
Virocomb-N Tab
RANBAXY LABORATORIES LTD ₹1275.00
Stavex 30-LN Tab
AUROBINDO PHARMA LTD ₹0.00
Lazid-N Tab
EMCURE PHARMACEUTICAL LTD ₹0.00

Uses of Lamivudine,nevirapine,zidovudine

The tablet formulation of Lamivudine + Nevirapine + Zidovudine is accessible. Lamivudine and Zidovudine fall under the category of nucleoside/nucleotide reverse transcriptase inhibitors, while Nevirapine is classified as a non-nucleoside reverse transcriptase inhibitor. This combination is employed for the treatment of HIV-1 infection.

Lamivudine,nevirapine,zidovudine Drug administaration and Dosage available

Follow your physician’s instructions when taking Lamivudine + Nevirapine + Zidovudine. Swallow the tablets whole and with food. Avoid crushing, chewing, or opening the tablets. The appropriate dosage and duration will be determined by your doctor, considering factors such as age, body weight, and the specific disease condition. Only discontinue the medication if advised to do so by your doctor.

Warnings, Precautions and Side Effects of Lamivudine,nevirapine,zidovudine

Warnings

Avoid Lamivudine + Nevirapine + Zidovudine if you are allergic to this medication, its components, or if you are pregnant or breastfeeding. Notify your doctor about any liver problems, hepatitis infection, kidney issues, or if you are undergoing dialysis. Inform your physician if you have any ongoing skin conditions, such as a rash. This tablet may interact with specific medications, potentially impacting their effectiveness or increasing the likelihood of side effects. It is crucial to disclose all your medications, including prescription, over-the-counter, and herbal supplements, to your doctor to prevent potential interactions.

Precautions

Lamivudine + Nevirapine + Zidovudine is not recommended for patients with anemia (low red blood cells) or neutropenia (low white blood cells). It is essential to inform your doctor if you have any liver disease, including hepatitis B or C, kidney disease, or if you are overweight. The administration of this medication is associated with hematologic toxicity (a decrease in blood cells), muscle weakness, liver diseases and infection, and lactic acidosis (an increase in acid levels due to metabolic issues in the body). It is not suitable for children weighing less than 35 kg. Additionally, Lamivudine, Nevirapine, and Zidovudine may lead to reduced fertility in females; discuss any concerns about fertility with your physician.

Side Effects

Nausea, diarrhea, headache, dizziness, cough, and difficulty sleeping are among the typical side effects associated with Lamivudine + Nevirapine + Zidovudine.

Word Of Advice

Adhere to your doctor’s guidance regarding high-risk activities, such as unprotected sex and handling personal items that may contain body fluids or blood, like toothbrushes, razor blades, and needles. It is recommended to engage in safe sex by using a condom to reduce the risk of contact with semen, blood, or vaginal secretions. In case you miss a dose of Lamivudine + Nevirapine + Zidovudine, take the next scheduled dose at its designated time; do not double the dose to compensate for a missed one.

Frequently Asked Question

No, continuing this Lamivudine + Nevirapine + Zidovudine as prescribed is important, even if you feel better. Stopping or interrupting treatment can lead to viral rebound and the development of drug resistance
No, Lamivudine + Nevirapine + Zidovudine cannot cure HIV. They are used as part of combination antiretroviral therapy (ART) to suppress the virus, improve the immune system, and prevent the progression of HIV infection. ART is a lifelong treatment for HIV.
While Lamivudine + Nevirapine + Zidovudine is effective in managing HIV infection in individuals who are already HIV-positive, they are not intended to prevent HIV transmission. It is necessary to use preventive measures like condoms to reduce the chance of acquiring HIV.
Yes, this Lamivudine + Nevirapine + Zidovudine may cause bone marrow suppression. Inform your physician if you experience any changes in your blood reports, such as increased or decreased RBC and WBC.