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Bupivacaine Hydrochloride

This page contains brief details about the drug bupivacaine hydrochloride, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Bupivacaine hydrochloride contains the active component Bupivacaine hydrochloride. It is a local anesthetic medication used for various medical procedures to numb a specific body area. It is commonly administered by injection near nerves to relieve pain during surgical procedures, childbirth, or other medical interventions. This anesthesia belongs to the class of drugs known as amide-type local anesthetics. It can be employed for surgical procedures, including orthopedic surgeries, cesarean sections, and dental procedures. It may also manage chronic conditions like postoperative pain or chronic pain syndromes. This medication should not be administered if there is an active infection at the intended injection site.

AVAILABLE BRANDS

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Bupicaine 0.25% Injection 20ml
THEMIS MEDICARE ₹39.00
Anawin 0.5% Injection
THEMIS MEDICARE ₹93.00
Anawin Heavy 5mg Injection
NEON LABORATORIES LTD ₹23.00

Mechanism of Action of Bupivacaine Hydrochloride

The therapeutic effect of bupivacaine hydrochloride is primarily due to its role as a local anesthetic. Upon administration, it blocks the transmission of nerve signals in the targeted area, leading to a temporary loss of sensation and pain relief. This effect enables various medical procedures to be conducted with reduced or eliminated pain.

Uses of Bupivacaine Hydrochloride

Bupivacaine Hydrochloride used in anesthesia for surgical procedures, labor, and delivery It is also used in chronic pain management.

Bupivacaine Hydrochloride Drug administaration and Dosage available

A healthcare provider typically gives Bupivacaine hydrochloride via injection. A healthcare provider will determine the recommended dosage based on age, weight, and specific purpose.

Warnings, Precautions and Side Effects of Bupivacaine Hydrochloride

Warnings

Bupivacaine hydrochloride carries warnings regarding its use, including the potential for cardiac effects, respiratory depression, allergic reactions, and local anesthetic systemic toxicity (LAST). LAST can manifest as symptoms like confusion, blurred vision, tremors, or cardiac arrest. central nervous system effects, impaired hepatic function, and neurologic effects. Rarely it causes methemoglobinemia and hypersensitivity reactions.

Precautions

Precautions to be taken when using bupivacaine hydrochloride include careful administration to avoid intravascular injection, monitoring of cardiac function and respiratory status during and after administration, caution in patients with impaired hepatic function or pre-existing cardiac or respiratory conditions, careful consideration of dosage and concentration to minimize the risk of systemic toxicity, close observation for signs of allergic reactions or neurologic complications, adherence to pediatric dosing guidelines, awareness of potential drug interactions, and individualized assessment of the risks versus benefits in pregnant, breastfeeding, and elderly patients.

Side Effects

Bupivacaine hydrochloride’s common side effects may include temporary numbness, tingling, muscle weakness at the injection site, dizziness, drowsiness, nausea, vomiting, headache, and itching. Serious side effects, although rare, may include allergic reactions (such as rash, itching, or swelling), respiratory depression (slowed breathing), cardiovascular effects (such as low blood pressure or abnormal heart rhythms), and neurologic effects (such as seizures or nerve damage).

Word Of Advice

When it comes to your health and medication, maintaining open communication with your healthcare provider is crucial. Provide them with a detailed overview of your medical history, including existing conditions, current medications, and any allergies. Elderly individuals might be more sensitive to bupivacaine hydrochloride due to age-related changes in metabolism and reduced cardiac reserve, which can heighten the risk of adverse reactions. Therefore, close monitoring and appropriate dose adjustments may be necessary.

Frequently Asked Question

Bupivacaine hydrochloride is primarily used as a local anesthetic for medical procedures, such as surgeries, dental procedures, or labor pain relief. Its use for cosmetic purposes, such as dermal fillers or facial rejuvenation, is less common and may vary depending on the situation.
While bupivacaine hydrochloride can potentially cause seizures as a rare side effect, it is generally considered safe for patients with a history of seizures. However, the healthcare professional will carefully evaluate the patient’s medical condition, seizure control, and the potential risks versus benefits.
The duration of the anesthetic effect of bupivacaine hydrochloride can vary depending on the specific formulation and administration technique. The effect can typically last several hours, providing prolonged pain relief. However, it is important to note that the duration of action can vary among individuals and may be influenced by factors such as the site of administration, dosage, and individual response.
When administered by trained healthcare professionals, Bupivacaine hydrochloride is generally safe for pediatric dental procedures. However, specific dosage considerations and age-appropriate formulations should be followed. The healthcare provider will carefully assess the child’s needs, considering the procedure’s complexity, duration, and overall health status.
Bupivacaine hydrochloride is generally not used for eye surgeries due to the potential risks associated with its use near the eye. Instead, ophthalmic surgeons typically use specific ophthalmic local anesthetics specifically formulated for eye procedures and have a better safety profile.

Disclaimer

The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.