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Bosutinib

This page contains brief details about the drug bosutinib, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Bosutinib is an anti-cancer medication that belongs to tyrosine kinase inhibitors. The drug was first approved in September 2012 for treating patients with chronic, accelerated, or blast-phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) who are resistant or can no longer benefit from other medications for CML. Later on, FDA approved bosutinib for the treatment of patients with newly-diagnosed chronic phase (CP) Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in December 19, 2017.

Mechanism of Action of Bosutinib

Bosutinib actively blocks the enzyme tyrosine kinase, specifically targeting certain enzymes in white blood cells. The Bcr-Abl gene, an oncogene created from the fusion of the breakpoint-cluster (Bcr) gene and the Abelson (Abl) tyrosine kinase gene, results in the formation of the Philadelphia chromosome. This gene produces an enzyme that promotes the progression of chronic myeloid leukemia (CML) by stimulating uncontrolled cell division. By inhibiting this enzyme, bosutinib helps control cell division, thereby managing the growth and spread of leukemia cells in CML.

AVAILABLE BRANDS

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Bonitar 100mg Tablet
SUN PHARMACEUTICAL INDUSTRIES LTD ₹774.00
Bonitar 400mg Tablet
SUN PHARMACEUTICAL INDUSTRIES LTD ₹2,420.00
Bosuvi 400mg Tablet
GLENMARK PHARMACEUTICALS LTD ₹7,912.00
Bosuvi 100mg Tablet
GLENMARK PHARMACEUTICALS LTD ₹4,227.00
Bosutris 100mg Tablet
MYLAN PHARMACEUTICALS PVT LTD ₹7,232.00

Uses of Bosutinib

Bosutinib is used to treat three stages of chronic myelogenous leukemia (CML): the chronic phase, accelerated phase, and blast phase, in patients who have previously been treated with one or more tyrosine kinase inhibitors (medicines for CML similar to bosutinib) but have become intolerant to them. Additionally, it is used to treat newly diagnosed chronic phase (CP) Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML).

Bosutinib Drug administaration and Dosage available

Bosutinib is available in oral tablet forms of 100 mg, 400 mg, and 500 mg. A healthcare professional will prescribe the medication. Your physician will determine the dose and frequency based on the severity of the disease, your weight, and height. For newly diagnosed chronic phase (Ph+) CML, the initial prescription is 400 mg orally once daily with food. For managing chronic, accelerated, or blast phase (Ph+) CML with resistance or intolerance to prior therapy, the prescribed dose is 500 mg orally once daily with food. Depending on how the medicine works for you and any side effects, your doctor may adjust the dose up to 600 mg once daily, reduce it, or interrupt treatment.

Warnings, Precautions and Side Effects of Bosutinib

Warnings

The drug may cause allergic reactions; notify your doctor if you see any signs of rash, itchy skin, redness, Swelling of your lips or tongue, sudden cough, and low blood pressure. Bosutinib causes infection. Inform your doctor immediately if you face any symptoms of infection or bleeding. Report the symptoms of decreased liver function, chest pain, and fluid buildup in the abdomen, face, and ankle areas to your doctor. It is not safe to take this medicine during pregnancy. It may harm an unborn baby. Tell your doctor immediately if you become pregnant, breastfeeding, or planning for pregnancy. This medicine may cause liver damage and kidney and heart problems; hence if you have any existing conditions, inform your doctor.

Precautions

Do not take PPIs (Proton pump inhibitors such as pantoprazole, omeprazole, and lansoprazole) while using this medication because this will reduce the effectiveness of bosutinib. Consider talking with your physician about all the other prescribed, over-the-counter or herbal medications you take. If you take antacids or H2 blockers (such as famotidine and ranitidine), take these medications at least 2 hours before or after bosutinib. Inform your physician if you are allergic to bosutinib, its ingredients, or other medications. Bosutinib may increase your chances of getting infected. To lower the chances of getting infected, avoid contact with people affected by infections such as cold or flu.

Side Effects

The common side effects of bosutinib are abdomen pain, anemia (low red blood cell counts), low platelet counts, nausea, diarrhea, vomiting, blood in your stools, tiredness, fever, cough, rash, headache, decreased platelet counts, tiredness, increased levels of liver enzymes, swelling of the ankles or swelling around the eyes, joint or muscle pains, bitter or metal taste in your mouth. This treatment can reduce the number of white blood cells in your blood. These cells fight infection. If the number of white blood cells is low, you will likely get an infection.

Word Of Advice

Take this medication by mouth with food as directed by your doctor, usually once daily. Swallow the medication whole. Do not crush, chew, or split the tablets. Use this medication regularly to get the most benefit from it. Remember to use it at the same time each day. This drug may make you dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely.

Frequently Asked Question

Bosutinib is administered orally (by mouth) in the form of a tablet.
Store Bosutinib at room temperature 20°C to 25°C (68°F to 77°F). Prevent it from moisture and keep it out of reach from children and pets.
Inform your physician if you are likely to develop an infection, symptoms of swelling in the face and ankle, or any signs of liver damage.
Do not breastfeed while taking Bosutinib and at least 2 weeks after the treatment because the drug may secrete in the milk and cause harmful effects on the baby.
Yes, bosutinib could cause infertility. Consider discussing it with your doctor if you are planning to get pregnant.

Disclaimer

The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.