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Bortezomib

This page contains brief details about the drug bortezomib, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Bortezomib is a first-generation proteasome inhibitor which was approved for its medical use on 13th May 2003.

Mechanism of Action of Bortezomib

Bortezomib is an anticancer medication that belongs to the category of medicines called proteasome inhibitors. it disrupts signalling cascades, interferes with transcription and promotes DNA damage, ultimately inducing programmed cell death to stop the growth and spread of cancer cells. Bortezomib is used in combination with other treatment like cyclophosphamide, doxorubicin, prednisone or rituximab.

AVAILABLE BRANDS

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Velcade 1mg Injection
JOHNSON & JOHNSON PVT LTD ₹15,322.00
Bortecad 2.5mg Injection
CADILA PHARMACEUTICALS LTD ₹1,869.00
Borviz 2.5mg Injection
INTAS PHARMACEUTICALS LTD ₹3,936.00
Bortero 2mg Injection
HETERO HEALTHCARE LTD ₹1,559.00

Uses of Bortezomib

Bortezomib has been developed to treat adult patients diagnosed with Multiple myeloma and mantle cell lymphoma.

Bortezomib Drug administaration and Dosage available

Bortezomib is available as a single-dose vial containing lyophilized powder for injection in doses of 1 mg, 2 mg, 2.5 mg, and 3.5 mg. Bortezomib Injection is intended for intravenous or subcutaneous administration only. Your healthcare provider will determine the precise dose based on your health condition and the route of administration.

Warnings, Precautions and Side Effects of Bortezomib

Warnings

Contact your doctor immediately if you experience increase in blood pressure, bleeding, fever or constipation. During the Bortezomib treatment, your doctor may periodically monitor your blood cell counts, platelets, blood sugar, electrolytes, liver and kidney parameters to prevent serious complications. Report to your doctor if you have been diagnosed with anaemia, liver problems, kidney disease, heart problem, etc. Get immediate medical attention if you experience itchy skin, rashes, or signs of infection or bleeding.

Precautions

Bortezomib can cause potential risk to the foetus. Hence it is advisable to use an effective contraception during treatment with bortezomib and for 7 months following the last dose. male patients with female partners of reproductive potential should use an effective contraceptive during treatment with bortezomib and for four months following the last dose. Report to your healthcare provider immediately if you or your female partner become pregnant during treatment or within 7 months after the last dose. It is not recommended to breastfeed during treatment with bortezomib and for two months after the last dose.

Side Effects

The common side effects that are likely to occur while you are on the treatment with Bortezomib are diarrhoea, rash, nausea, thrombocytopenia, neutropenia, tiredness, fever, vomiting, constipation, loss of appetite, etc. Serious side effects include heart problems, dizziness, confusion, tumor lysis syndrome, peripheral neuropathy, respiratory problems, liver problems, low blood cell counts. If you experience any allergic reactions such as swelling of lips, eyes, face, or tongue, hives, skin rashes, breathing trouble, report to your doctor immediately.

Word Of Advice

Bortezomib can cause dizziness, postural hypotension and confusion. Therefore, it is advisable to avoid driving or doing activities that require your focus during this treatment. Drink sufficient fluids to avoid dehydration. Your blood sugar level frequently If you are taking antidiabetic medication and report your physician if you notice any fluctuations in your blood sugar levels.

Frequently Asked Question

Bortezomib is unsafe during pregnancy as it has the tendency to cause fetal harm. Your healthcare provider will conduct pregnancy test before and during treatment with Bortezomib to rule out pregnancy and prevent complications.
People who have experienced allergic reactions to Bortezomib, boron and mannitol should not take Bortezomib Injection. This injection is not intended for administration through intrathecal (spinal) route.
Diarrhoea, rash, nausea, thrombocytopenia, neutropenia, tiredness, peripheral neuropathy, fever, vomiting, constipation, loss of appetite are the most common side effects of Bortezomib.
Reach out to your health care provider and immediate medical attention if you experience increase in blood pressure, bleeding, fever, abnormal heart rhythm, skin rashes, neuropathic pain, weakness or constipation.
During treatment with Bortezomib, your health care provider will monitor RBC, WBC, platelets, liver, blood glucose and kidney parameters.

Disclaimer

The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.