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Bendamustine

This page contains brief details about the drug bendamustine, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Bendamustine is an antineoplastic drug that belongs to the category of medicines known as alkylating agents. It was approved by the FDA in 2008 to treat certain types of cancers.

Mechanism of Action of Bendamustine

It is an alkylating drug, which works by causing DNA damage and disrupting the cell cycle, leading to cancer cell death. It forms covalent bonds with DNA, inhibits DNA repair enzymes, and blocks cell cycle progression. Bendamustine is used as a cytotoxic drug that kills cancer cells by inhibiting their DNA and cell cycle.

AVAILABLE BRANDS

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Benzz 180mg Injection
INTAS PHARMACEUTICALS LTD ₹3705.00
Zumustin 100mg Injection
INTAS BIOPHARMA ALS LTD ₹0.00
Benzz 45mg Injection
INTAS PHARMACEUTICALS LTD ₹927.00
Benzz 100mg Injection
INTAS PHARMACEUTICALS LTD ₹3555.00

Uses of Bendamustine

Bendamustine, an alkylating agent, is utilized in the treatment of Chronic lymphocytic leukemia (a cancer affecting the blood and bone marrow), Non-Hodgkin’s lymphomas (a type of cancer originating in the lymph system, a part of the immune system), and Multiple myeloma (a cancer involving plasma cells, a subtype of white blood cells).

Bendamustine Drug administaration and Dosage available

Bendamustine is a prescription medication available in injectable form. A healthcare professional in a hospital setting will administer this injection intravenously into a vein in your arm or hand; it should not be self-administered. Treatment should not commence if your white blood cell count falls below specified levels, which your doctor will monitor regularly. Your doctor will determine the appropriate dosage based on your disease status and other relevant factors. Typically, Bendamustine Injection is administered approximately 30 minutes before your chemotherapy or immediately before anesthesia for surgery. Throughout the infusion, you will be closely monitored for any adverse effects or reactions to the medication. The infusion usually lasts several hours, and you may require multiple infusions over several weeks.

Warnings, Precautions and Side Effects of Bendamustine

Warnings

Bendamustine is not advised for patients with hypersensitivity reactions, as it may induce allergic responses in certain individuals. Allergic reaction symptoms may include itching, difficulty breathing, swelling of the face or throat, and a rapid heartbeat. If you encounter any of these symptoms, seek immediate medical attention. Additionally, Bendamustine is contraindicated in pregnant women or those who may become pregnant during therapy, as it can cause harm to the fetus when administered to pregnant individuals. Patients with severe immunosuppression due to bone marrow suppression should also avoid this medication.

Precautions

Bone marrow suppression can result in decreased blood cell counts, potentially increasing the risk of infection, anemia, or excessive bleeding. Your doctor will regularly monitor your blood counts throughout treatment and may adjust the dosage or frequency of administration as needed. If you intend to father a child, it is recommended to refrain from doing so during treatment with Bendamustine for infusion and for up to 6 months after treatment cessation. The use of this medication may heighten the risk of certain types of skin cancer, specifically non-melanoma skin cancer. Seek immediate medical advice from your doctor for further guidance.

Side Effects

Common side effects associated with this medication include headaches, insomnia, fatigue, loss of appetite, and rashes. Additionally, serious side effects may include myelosuppression, tumor lysis syndrome, and hepatotoxicity. If you experience any of these side effects or if they persist longer than expected, it’s important to inform your healthcare provider.

Word Of Advice

Bendamustine carries risks for fetal development and nursing infants, so it’s crucial to discuss contraception options and avoid breastfeeding during treatment. This medication can induce fatigue, so it’s advisable for patients to prioritize rest and self-care during treatment. If you experience dizziness, nausea, or tiredness while on Bendamustine, refrain from driving or operating heavy machinery. Adherence to the scheduled dosage is essential, but if a dose is missed, promptly contact your doctor to reschedule. Store Bendamustine injection in the refrigerator (2°-8°C) without freezing and keep it out of reach of children. Given its tendency to increase the risk of bleeding and bruising, caution should be exercised when handling sharp objects or engaging in activities that may lead to injury.

Frequently Asked Question

Bendamustine is a chemotherapy drug used to treat various types of cancers, including non-Hodgkin’s lymphoma, chronic lymphocytic leukaemia, and multiple myeloma.
Bendamustine solution is administered into a vein as a short-term infusion over 30 – 60 minutes.
Bendamustine works by damaging the DNA in cancer cells, preventing them from multiplying and spreading.
Yes, bendamustine is often used in combination with other chemotherapy drugs to improve treatment outcomes.

Disclaimer

The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.