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ATAZANAVIR
This page contains brief details about the drug atazanavir, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
Atazanavir is an antiretroviral medication containing the active constituent atazanavir. Along with other antiretroviral medications, it is utilized to treat HIV-1 infection. The human immunodeficiency virus (HIV-1) targets and kills immune system cells; if left untreated, the body’s capacity to fight diseases declines and results in death. Lactose can be found in this medicine. If you are intolerant to sweets, let your doctor know. Atazanavir received FDA approval on June 20, 2003, to treat HIV-1 infection in adults.
Mechanism of Action of Atazanavir
Atazanavir functions by inhibiting the replication of HIV. Acting as a protease inhibitor, it hinders the activity of the HIV protease enzyme, thereby halting the production of mature and infectious viral particles.
By diminishing the viral load and decelerating the advancement of HIV infection, this antiviral medication aids in preserving immune function, elevating CD4 cell counts, and decreasing the likelihood of opportunistic infections. Such therapeutic efficacy empowers individuals with HIV to sustain a healthier immune system and enhance their long-term prognosis.
Uses of Atazanavir
Atazanavir is used to treat HIV -1 Infection.
Atazanavir Drug administaration and Dosage available
Atazanavir Tablet is taken orally. The medication is taken once a day, either with or can be taken without food, as directed by your healthcare provider. Swallow the capsule or tablet whole without crushing or chewing it.
Warnings, Precautions and Side Effects of Atazanavir
Warnings
Atazanavir comes with several critical warnings. These encompass the potential for severe skin reactions like Stevens-Johnson syndrome or toxic epidermal necrolysis, risks of liver issues and pancreatitis, occurrence of immune reconstitution syndrome, possibility of QT prolongation leading to irregular heartbeat, kidney complications, heightened risk of diabetes and hyperglycemia, fat redistribution, likelihood of hypersensitivity reactions, and potential for drug interactions.
Precautions
When taking atazanavir, it’s important to observe certain precautions. Regular monitoring of liver function is advised, and close attention should be paid to kidney function. Individuals with pre-existing heart conditions or those using medications that prolong the QT interval should proceed with caution. Monitoring of blood sugar levels may be necessary, particularly for individuals with diabetes. Any unusual skin reactions or signs of hypersensitivity should be reported promptly to a healthcare professional.
Side Effects
Atazanavir may induce several side effects. Common ones encompass nausea, diarrhea, headache, rash, and abdominal pain or discomfort. Serious side effects may include severe skin reactions, liver problems, pancreatitis, and immune reconstitution syndrome.
Word Of Advice
It is crucial to prioritize safety when considering using Atazanavir or other medication. Avoid its use during breastfeeding to protect the developing fetus. Cautious should be taken in existing heart conditions or medications that prolong the QT interval. Regular monitoring of blood sugar levels is important for individuals with diabetes. By following these precautions and promptly seeking medical attention for any concerning symptoms, individuals can ensure this medication’s safe and effective use and optimize their overall treatment experience.
Frequently Asked Question
Yes, Atazanavir, like other HIV medications, can potentially cause changes in body fat distribution. This may include increased fat in the abdomen, breasts, and back of the neck, while the face, arms, and legs may experience fat loss. It is known as lipodystrophy.
Atazanavir may interact with hormonal contraceptives, such as birth control pills, reducing their effectiveness. Additional or alternative contraceptive methods, such as barrier methods, should be used while taking it. Consult with a healthcare provider for appropriate contraceptive recommendations.
In some cases, Atazanavir has been associated with mood changes, including depression and anxiety, if you experience significant changes in mood or mental health while taking it.
Atazanavir can be prescribed for children with HIV infection, but the dosing and usage may differ compared to adults. The decision to use this medication in children should be made by a pediatric HIV specialist, considering factors such as age, weight, and other individual considerations.
Limited studies are available on Atazanavir’s effects on fertility or sperm quality. While some studies have suggested potential effects on sperm parameters, it is generally considered that the impact on fertility is unlikely. Discuss your fertility or reproductive health concerns while taking this medicine with a healthcare provider.
Disclaimer
The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.