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APREPITANT

This page contains brief details about the drug aprepitant, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

The U.S. FDA-approved Aprepitant to prevent nausea and vomiting due to chemotherapy on 26th March 2003.

Mechanism of Action of Aprepitant

The Aprepitant capsule inhibits the activity of neurokinin, a natural substance in the brain responsible for inducing nausea and vomiting. By blocking this action, the medication lessens the intensity of nausea and vomiting triggered by chemotherapy.

Uses of Aprepitant

Aprepitant is used to prevent nausea and vomiting due to chemotherapy in adults and children of twelve years and older.

AVAILABLE BRANDS

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Opilo 125mg/80mg Capsule
ABBOTT ₹1091.00
Piptashil 125mg/80mg Capsule
SHILPA MEDICARE LTD ₹758.00
Aprecap 125mg/80mg Capsule
GLENMARK PHARMACEUTICALS LTD ₹480.00
Apretero 125mg/80mg Capsule
HETERO HEALTHCARE LTD ₹415.00

Aprepitant Drug administaration and Dosage available

Take the Aprepitant capsule whole with water; do not crush or chew it. You can take these capsules with or without food, but do not exceed the recommended dose. Your doctor will prescribe the appropriate dosage based on your individual medical condition. Only discontinue Aprepitant if your doctor instructs you to do so.

Warnings, Precautions and Side Effects of Aprepitant

Warnings

Prior to taking this capsule, notify your doctor if you have liver disorders, as the liver plays a vital role in metabolizing medication. Your doctor may need to monitor your liver function accordingly. Additionally, be aware that certain medications, including Pimpzide, Terfenadine, and Cisapride, may interact with Aprepitant, potentially diminishing its efficacy and leading to adverse effects. It is not advisable to administer this medication to children under the age of 12.

Precautions

Before initiating treatment, your doctor may conduct liver function tests. Notify your physician if you have any allergic reactions to Aprepitant. Additionally, inform your doctor if you are pregnant, suspect you might be pregnant, or are planning to conceive, as your physician will prescribe Aprepitant only if deemed necessary. For further details, consult your doctor.

Side Effects

Common side effects associated with Aprepitant include fatigue, elevated liver enzymes, indigestion, constipation, decreased appetite, hiccups, and headaches.

Serious side effects may include allergic reactions such as rash, itching, difficulty breathing, or swallowing. If experiencing any of these, seek immediate medical attention.

Word Of Advice

Keep stored at room temperature between 20°C to 25°C. Store out of reach and sight of children. Store in its original packaging to shield from moisture. For further inquiries, consult your doctor. If a dose is missed, do not double up on the next dose. Contact your doctor promptly if a double dose is taken accidentally.

Frequently Asked Question

Aprepitant can be taken with other antiemetic drugs to provide more comprehensive prevention of chemotherapy-induced nausea and vomiting.
Aprepitant is primarily used to prevent nausea and vomiting caused by chemotherapy or surgery, but it may also be used to treat other conditions, such as migraine headaches.
Because the Aprepitant is initially gets metabolized in the liver. Hence patients with liver disorders will feel difficult to metabolize this medicine which may lead in increase the risk of side effects.
You need to inform if you have any underlying liver conditions if you are allergic to Aprepitant and if you are intolerant to sucrose or any other sugar.
Aprepitant should only be used during pregnancy if the potential benefits outweigh the potential risks to the fetus.

Disclaimer

The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.