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AMBRISENTAN,TADALAFIL

This page contains brief details about the drug ambrisentan,tadalafil, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

The U.S. FDA-approved Ambrisentan + Tadalafil for pulmonary arterial hypertension (PAH) on June 15, 2007. Ambrisentan + Tadalafil belongs to the medication class known as an antihypertensive. Tadalafil is a type of medication called phosphodiesterase-5 (PDE5) inhibitor, whereas Ambrisentan belongs to an endothelin receptor antagonist.

AVAILABLE BRANDS

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Endobloc T Kit Tablet ₹1,760.00
Endobloc 10mg Tablet ₹2,591.00
Volibris 5MG Tablet ₹2,469.53
Endobloc 5mg Tablet ₹1,663.00

Mechanism of Action of Ambrisentan,tadalafil

Tadalafil operates by relaxing blood vessels in the chest region, enhancing blood flow to the lungs and alleviating strain on the heart. Ambrisentan acts by inhibiting the action of endothelin, a natural substance that narrows blood vessels and elevates blood pressure. Through relaxing the constricted pulmonary arteries, Ambrisentan enhances blood supply to the lungs and reduces blood pressure.

Uses of Ambrisentan,tadalafil

Ambrisentan + Tadalafil treats pulmonary arterial hypertension (PAH). It functions by inducing relaxation in the blood vessels within the lungs.

Ambrisentan,tadalafil Drug administaration and Dosage available

Follow your doctor’s guidance on taking Ambrisentan + Tadalafil. Typically, the tablets should be taken with or without food, and it is important not to crush, chew, or open the medicine. The appropriate dosage and duration will be determined by your doctor based on factors such as age, body weight, and the specific disease condition. Do not cease taking the tablets unless your doctor instructs you to do so.

Warnings, Precautions and Side Effects of Ambrisentan,tadalafil

Warnings

Prior to using Ambrisentan + Tadalafil, it’s important to note that the medication should be avoided if you have allergies to its components. Refrain from taking this medicine if you have liver conditions or low blood pressure. Pregnant or breastfeeding individuals, those using organic nitrates or GC stimulators, with a history of vision loss in one eye, or individuals with idiopathic pulmonary fibrosis (IPF) should also avoid this medication. Inform your doctor if you have issues like penis deformation, swelling in the extremities, prolonged or painful erection (priapism), cancer (leukemia, multiple myeloma), severe kidney problems, abnormalities of red blood cells, or loss of hearing before initiating the treatment.

Precautions

Inform your doctor about your pregnancy, plans for pregnancy, ongoing breastfeeding, or any suspicion of being pregnant. This medicine is not recommended for use in children under 18 years old. Before starting the treatment, provide your doctor with information about hypotension, a history of heart failure, or severe liver disease. Also, notify your doctor if you have recently experienced a stroke or myocardial infarction. Share information about any history of lung conditions, anemia, or edema (fluid retention). Blood tests may be conducted by your doctor to check for anemia and assess liver functionality. The impact of the medicine on driving or operating machinery is uncertain, so consult your doctor for more specific advice.

Side Effects

The common side effects of Ambrisentan + Tadalafil include skin redness, vomiting, chest pain, ringing in the ears, abnormal liver function, and constipation. Serious side effects that may occur while taking Ambrisentan + Tadalafil include edema, anemia, hypotension, allergic reactions, sudden loss of vision, priapism (prolonged and painful erection), weakness, and problems with eyesight, including blurry vision. If you experience any of these serious side effects, seek immediate medical attention.

Word Of Advice

Discuss all your underlying medical conditions with your doctor. Follow your doctor’s advice and do not stop the medication without consultation. Avoid doubling the dose to compensate for a missed one. Report any serious side effects to your doctor, who will guide you on potential dose adjustments. Attend regular follow-up appointments to monitor your response and potential side effects. Keep in touch with your doctor for further information and guidance. Moreover, if you experience blurred vision or other visual issues, seek immediate attention from an eye doctor. Some patients may notice a reduction in the effectiveness of this medicine after regular use for a few months. If you observe such changes, inform your doctor promptly.

Frequently Asked Question

To manage the side effects of Ambrisentan + Tadalafil, follow the prescribed dosage, and report side effects promptly. Stay hydrated, and monitor your liver function regularly. Maintain a healthy lifestyle, and attend follow-up appointments. 
No, Ambrisentan + Tadalafil is unsafe to consume during pregnancy. Consult your medical professional regarding the use of Ambrisentan + Tadalafil during pregnancy. Also do not breastfeed. It is advised to use contraception to avoid getting pregnant.
Common side effects of Ambrisentan + Tadalafil include drowsiness, dizziness, dry mouth, blurred vision, weight gain, and changes in mood or behavior. It is crucial to consult your doctor for any concerns or persistent side effects.
If you miss a tablet dose, take it as soon as possible. However, if it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose the Ambrisentan + Tadalafil.