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AMANTADINE

This page contains brief details about the drug amantadine hydrochloride, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

The FDA approved amantadine hydrochloride for medical use on 24/08/2017 to treat uncontrolled, involuntary muscle movements in Parkinson’s patients.

Mechanism of Action of Amantadine Hydrochloride

Amantadine increases dopamine levels in the brain, alleviating Parkinson’s disease symptoms. As an antiviral agent, it interferes with flu viruses, blocking cell entry and cell replication.

AVAILABLE BRANDS

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Parkitidin 100mg Tablet ₹153.00
Amantrel 100 MG Tablet ₹222.27

Uses of Amantadine Hydrochloride

Primarily employed for the treatment of Parkinson’s disease, a neurological disorder impacting movements, Parkitidin 100mg tablet is known for its beneficial effects on Parkinsonism. While initially developed as an antiviral for preventing influenza A, its usage is infrequent due to high resistance levels.

Amantadine Hydrochloride Drug administaration and Dosage available

Adrenaline bitartrate injection is provided in the form of 100mg tablets designed for oral use. Ingest the tablets whole with water; avoid crushing them. Your physician will determine the appropriate dose and frequency based on factors such as disease severity, body weight, and other relevant considerations.

Warnings, Precautions and Side Effects of Amantadine Hydrochloride

Warnings

Prior to taking amantadine, consider certain conditions. It is not advisable to use this tablet if you are allergic to amantadine hydrochloride or its components, have lactose intolerance, epilepsy (seizures), ulcers, severe kidney disease, or if you are pregnant, planning pregnancy, or breastfeeding. Seek advice from your doctor if there is uncertainty. Furthermore, consult your doctor before using amantadine if you have liver or kidney issues, heart problems, mental illnesses like schizophrenia (inability to think, feel, or behave), or glaucoma (increased pressure in the eyes). Communicating your medical history and current medications is crucial before initiating treatment.

Precautions

Prior to taking amantadine, inform your doctor if you are pregnant or planning to conceive. The use of amantadine is not recommended during pregnancy as it may pose potential harm to your baby. The same caution applies to breastfeeding, as the medication can pass into breast milk. If you have lung or liver diseases, consult your doctor before taking amantadine. Additionally, it is advisable to avoid alcohol while on this medication, and exercise caution when driving or operating machinery, as it may cause dizziness and blurred vision. Prioritize safety, keep your doctor informed, and adhere closely to these guidelines.

Side Effects

Certain side effects of amantadine hydrochloride can be severe, such as convulsions (fits) and fainting. More frequently observed side effects may include swollen ankles, red blotchy spots on the skin, depression, confusion, difficulty sleeping, nightmares, nervousness, headaches, dizziness, difficulty controlling movements, slurred speech, fast or irregular heartbeat, and low blood pressure upon standing up. Constipation, sweating, and dry mouth are also reported side effects. It is crucial to be mindful of these possible reactions and seek advice from a healthcare professional if these symptoms manifest during the course of the medication.

Word Of Advice

During the course of amantadine treatment, if you, your family, or your caregiver observe any unusual urges or cravings that you find challenging to resist, promptly inform your doctor. These impulses may lead to engaging in activities harmful to yourself or others, such as excessive gambling, eating, spending, or increased sexual thoughts or behaviors, known as impulse control disorders. It is essential to report these symptoms to your doctor, as adjustments or discontinuation of your amantadine hydrochloride dosage may be necessary. Moreover, if you experience blurred vision or other visual issues, seek immediate attention from an eye doctor. Some patients may notice a reduction in the effectiveness of this medicine after regular use for a few months. If you observe such changes, inform your doctor promptly.

Frequently Asked Question

Do not stop taking Amantadine hydrochloride suddenly, even if you feel better, without a doctor’s advice. Stopping suddenly may cause worsening symptoms or side effects such as fever, rapid heartbeat, or loss of bladder control. Your doctor will decide when and how to reduce the dose gradually. 
Taking amantadine with food or milk is recommended to avoid an upset stomach. Also, taking the last dose several hours before bedtime can prevent insomnia.
Yes, amantadine is mostly removed from the body through the kidneys. If your kidneys are not working well, amantadine can build up in your blood, causing more side effects and potential harm.
Yes, People taking the recommended dose of amantadine commonly experience side effects such as nausea, difficulty sleeping, and feelings of dizziness or lightheadedness.