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ALPROSTADIL

This page contains brief details about the drug alprostadil, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

The U.S. FDA approved Sotalol in 1996 and used to treat erectile dysfunction (ED), peripheral arterial disease (PAD), patent ductus arteriosus (PDA) in Infants and also for diagnostic purposes.

Mechanism of Action of Alprostadil

Alprostadil selectively binds to receptors on smooth muscle cells in blood vessels and various tissues. This binding initiates biochemical events that result in vasodilation. Specifically, it induces the relaxation of smooth muscle cells in the walls of blood vessels, particularly in the penis when employed for erectile dysfunction. This process aims to promote the relaxation of smooth muscle cells, thereby enhancing blood flow to specific areas of the body, depending on the intended use.

AVAILABLE BRANDS

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Alpostin 500mcg Injection ₹5,718.54
Prostaver 500mcg Injection ₹5,650.00
Prostal 500mcg Injection ₹5,819.00

Uses of Alprostadil

It can be employed to enhance blood circulation in individuals with peripheral arterial disease (PAD), a condition characterized by reduced blood flow to the extremities, typically affecting the legs. In newborns with specific heart conditions, like PDA, it has the capacity to facilitate the opening of a blood vessel known as the ductus arteriosus. Furthermore, it finds application in diagnostic examinations, such as penile Doppler ultrasound studies, to evaluate blood flow in specific areas of the body and assess erectile function.

Alprostadil Drug administaration and Dosage available

Alprostadil is provided in injection form and is administered through intracavernosal injection (into the penis) by a healthcare provider during scheduled appointments. The appropriate dosage for your situation will be determined by your doctor, taking into account factors such as age and physical condition.

Warnings, Precautions and Side Effects of Alprostadil

Warnings

Alprostadil has the potential to induce priapism, characterized by a painful and prolonged erection lasting more than four hours. Prolonged use of this medication for erectile dysfunction (ED) may result in penile fibrosis, causing scarring that could impact erectile function. Although uncommon, severe allergic reactions to this medication can occur. Alprostadil may also lead to a decrease in blood pressure, possibly causing dizziness or fainting. Additionally, there is an increased risk of bleeding, especially in individuals with bleeding disorders or those taking anticoagulant medications (blood thinners).

Precautions

In the event of priapism, promptly seek medical attention, as delayed treatment can result in potential damage to the penis. If you encounter a rash, itching, swelling, severe dizziness, or difficulty breathing, seek immediate medical assistance. Exercise caution if you have low blood pressure or are taking medications that lower it. Individuals with underlying heart conditions should approach its use cautiously due to potential cardiovascular effects. Adhering to the prescribed dosage and administration instructions for this medication is crucial, and if any concerns or adverse effects arise, consult with a healthcare provider.

Side Effects

Common side effects during Alprostadil treatment include pain or discomfort, penile burning or tingling, urethral irritation, headache, flushing, and flu-like symptoms. Should you experience priapism, penile fibrosis, allergic reactions, low blood pressure, cardiovascular effects, or bleeding, promptly inform your doctor.

Word Of Advice

Administer Alprostadil under the supervision of a healthcare professional to determine the appropriate dosage and method. Be vigilant for priapism (prolonged erection) and seek immediate assistance if it occurs. Inform your healthcare provider of any underlying medical conditions, such as bleeding disorders, heart conditions, or liver disease, as dose adjustments or special precautions may be necessary. Exercise caution if you have penile abnormalities or a predisposition to priapism. Monitor the usage of this medication in infants, weighing the benefits against potential risks. Refrain from use if you are allergic to it or its components. Consume alcohol cautiously and be mindful of potential medication interactions. Evaluate how this medication affects you before engaging in activities like driving or operating machinery. Discuss its use during pregnancy and breastfeeding with your healthcare provider. Adhere to storage instructions for safe and effective utilization.

Frequently Asked Question

Priapism, a prolonged and painful erection, is a potential side effect of Alprostadil. It is a serious condition and requires immediate medical attention.
Alprostadil is primarily used in men, but some applications exist for women, such as treating sexual arousal disorders or facilitating certain medical procedures. Its use in women should be discussed with a healthcare provider.
Alprostadil is a prescription medication and should only be used under medical supervision for legitimate medical reasons. Its recreational use is not recommended and can be dangerous.
Your healthcare provider should determine the duration of Alprostadil use for eraction dysfunction. Long-term use should be monitored for potential side effects.