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ALPELISIB
This page provides concise information regarding the medication alpelisib, including its indications, dosage and administration details, mechanism of action, associated brands with strengths, warnings, and prevalent side effects.
Background and Date of Approval
Alpelisib is an anticancer medication which was approved for its medical use on 24th May 2019.
Mechanism of Action of Alpelisib
Alpelisib, categorized as a kinase inhibitor within targeted cancer drug therapy, specifically targets the mutation of PI3K genes. These genes are prevalent in hormone receptor-positive and human epidermal growth factor receptor 2 (HER2) breast cancers. Alpelisib functions by disrupting the cell signaling of PI3K genes, thereby impeding the growth and dissemination of cancer cells. Typically, it is administered in conjunction with other chemotherapy agents, such as Fulvestrant.
AVAILABLE BRANDS
Uses of Alpelisib
Alpelisib Tablet is designed for the treatment of advanced and metastatic breast cancer in postmenopausal women and men who have ceased responding to alternative therapies. It demonstrates notable efficacy against breast cancers characterized by the mutation in the PIK3CA gene, specifically those of hormone receptor-positive and human epidermal growth factor receptor 2 (HER2) origin.
Alpelisib Drug administaration and Dosage available
Alpelisib is presented in the form of film-coated tablets, available in doses of 150mg, 200mg, and 200+50mg. It is essential to swallow the tablet whole with a glass of water, avoiding any crushing or chewing.
Warnings, Precautions and Side Effects of Alpelisib
Warnings
If you encounter symptoms such as diarrhea, abdominal pain, chest discomfort, or difficulty breathing, promptly seek assistance from your healthcare provider. Persistent diarrhea can result in significant dehydration and potential kidney injury. Throughout the course of Alpelisib Tablet treatment, your physician may conduct periodic monitoring of your complete blood count and blood glucose levels to avert potential serious complications. It is crucial to inform your doctor of any pre-existing conditions, such as bleeding disorders, diabetes, heart issues, liver disease, or kidney problems.
Precautions
Alpelisib Tablet has the potential to induce fertility issues in both men and women. If this is a concern for you, it is advisable to have a discussion with your healthcare provider before initiating treatment with Alpelisib Tablet. Pregnant women are discouraged from using this tablet due to its capacity to cause harm to the fetus. Prior to commencing treatment, notify your healthcare provider if you are currently pregnant or planning to conceive. For women of reproductive potential, it is recommended to undergo a pregnancy test at least 7 days before starting Alpelisib treatment. Additionally, consult with your healthcare provider about employing effective contraceptive methods during the course of treatment and for one week after the last dose of Alpelisib.
Side Effects
Anticipated side effects during Alpelisib Tablet treatment include rash, decreased appetite, mouth sores, nausea, tiredness, weakness, vomiting, weight loss, hair loss, and alterations in blood tests. Additionally, there is a potential for Alpelisib Tablet to cause nerve damage at the tablet site. If you encounter weakness, breathing difficulty, cough, chest pain, or allergic reactions following the administration of this tablet, promptly contact your healthcare provider.
Word Of Advice
Diarrhea can be a side effect of Alpelisib. If the diarrhea persists or if you encounter severe stomach pain, contact your healthcare provider. Ensure a balanced diet. If you feel fatigued or weakened, it is advisable to refrain from driving or operating machinery.
FAQs
Is Alpelisib Tablet used as a monotherapy to treat cancer?
Alpelisib Tablet is prescribed in combination with fulvestrant to treat breast cancer that is hormone receptor-positive and human epidermal growth factor receptor 2 (HER 2)-negative.
Is it safe to use Alpelisib Tablet during pregnancy?
Alpelisib Tablet is not recommended for pregnant women due to its ability to cause fetal harm. Inform your healthcare provider before starting this treatment if you are pregnant or planning to have a baby.
Is Alpelisib Tablet safe to use during breastfeeding?
There is no sufficient information regarding the impact of Alpelisib Tablet on breastfeeding. Tell your healthcare provider if you are a breastfeeding mother or planning to breastfeed your child.
Disclaimer
The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.