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Alfuzosin Hcl,dutasteride

This page provides concise information about the medication containing alfuzosin HCl and dutasteride, including its indications, dosage and administration guidelines, mechanism of action, related brands with strengths, as well as warnings and common side effects.

Background and Date of Approval

Combining Alfuzosin HCl and Dutasteride in a single tablet introduces two active ingredients. Alfuzosin HCl falls under the category of alpha-adrenoreceptor antagonists, while Dutasteride belongs to the group of medications known as 5-alpha-reductase inhibitors. The FDA has approved this combination for the treatment of Benign Prostatic Hyperplasia (BPH).

Mechanism of Action of Alfuzosin Hcl,dutasteride

Alfuzosin functions as an alpha-1 adrenergic receptor blocker, selectively relaxing the smooth muscles in the prostate gland and the bladder neck. This action alleviates urinary symptoms associated with BPH. On the other hand, Dutasteride acts as a 5-alpha-reductase inhibitor, reducing the production of dihydrotestosterone (DHT), a hormone responsible for prostate enlargement.

AVAILABLE BRANDS

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Alfusin D 10mg Tablet
CIPLA LTD ₹543.04
Alfugress D Tablet
LARENON HEALTHCARE LTD LACTUS- ₹185.00

Uses of Alfuzosin Hcl,dutasteride

Alfuzosin HCl + Dutasteride is employed to alleviate symptoms linked to benign prostatic hyperplasia in men (enlarged prostate). Benign prostatic hyperplasia refers to the non-cancerous growth of the prostate gland, leading to urinary challenges such as difficulty in urination, a frequent or urgent need to urinate, and urinary dribbling.

Alfuzosin Hcl,dutasteride Drug administaration and Dosage available

Alfuzosin HCl + Dutasteride is employed to alleviate symptoms linked to benign prostatic hyperplasia in men (enlarged prostate). Benign prostatic hyperplasia refers to the non-cancerous growth of the prostate gland, leading to urinary challenges such as difficulty in urination, a frequent or urgent need to urinate, and urinary dribbling.

Warnings, Precautions and Side Effects of Alfuzosin Hcl,dutasteride

Warnings

Avoid taking Alfuzosin HCl + Dutasteride if you have severe liver disease or hepatic impairment. The metabolism of this drug occurs in the liver, so severe liver dysfunction may impact the clearance of these medications, potentially leading to adverse effects. Exercise caution when using this tablet in individuals with moderate to severe kidney impairment; dose adjustments may be necessary, and close monitoring of renal function is advised. If you have plans for cataract surgery or any other eye procedure, inform your ophthalmologist that you are taking this tablet, as the medication has been associated with intraoperative floppy iris syndrome (IFIS), which can complicate the surgical procedure.

Precautions

Alfuzosin HCl + Dutasteride has the potential to induce a drop in blood pressure, resulting in orthostatic hypotension (a sudden drop in blood pressure upon standing up). Caution should be exercised when using this drug in individuals with a history of orthostatic hypotension or those prone to low blood pressure. It is not advisable for adolescents and children under the age of 18. This medication is specifically intended for use in men and should not be taken by women.

Side Effects

Typical side effects associated with Alfuzosin HCl + Dutasteride include impotence, decreased libido, ejaculation disorder, headache, nausea, abdominal pain, upper respiratory tract infection, breast enlargement in males, and breast tenderness in males.

Word Of Advice

This medication has the potential to lower blood pressure, leading to dizziness or fainting, particularly when transitioning between positions (from lying down to standing up). To minimize the risk, stand up slowly and gradually from a sitting or lying position. It is crucial to stay well-hydrated while taking Alfuzosin HCl + Dutasteride. Consume sufficient water throughout the day unless otherwise advised by your healthcare provider. If you miss a dosage, take it as soon as you remember. If the next dose is approaching, skip the missed one, and do not double up to compensate for a missed dose.

Frequently Asked Question

Yes, Alfuzosin Hcl + Dutasteride can be taken at any time of the day. However, taking it at the same time each day is generally recommended for better medication adherence. It can be taken with or without food, as directed by your healthcare provider.
Certain supplements or herbal products may interact with Alfuzosin Hcl + Dutasteride, affecting its effectiveness or increasing the risk of side effects. It is important to inform your healthcare provider about all your supplements or herbal products before starting or modifying your medication regimen.
The long-term effects of taking Alfuzosin Hcl + Dutasteride can vary from person to person. There have been some reports of hepatotoxicity (liver damage) associated with alfuzosin use, although this is considered rare. It is essential to monitor liver function through regular blood tests if you take alfuzosin for an extended period.
During the initial treatment period, some individuals may experience a more rapid response, while others may require more time to see significant improvements. It is essential to continue taking Alfuzosin Hcl + Dutasteride as your healthcare provider prescribes, even if you do not see immediate results.
No, Alfuzosin Hcl + Dutasteride is specifically indicated for use in men and should not be taken by women.
Alfuzosin Hcl + Dutasteride may cause dizziness or drowsiness in some individuals, affecting your ability to drive or operate machinery safely. If you experience these side effects, avoiding activities requiring alertness is advisable.

References

  1. Sanofi, Electronic medicines compendium (EMC), [Revised on Sept 2020] [ Accessed on 13th  June 2023], https://www.medicines.org.uk/emc/files/pil.1475.pdf
  2. Rivopharm UK Ltd, US Food and Drug Administration, [Revised on March 2017] [ Accessed on 13th  June 2023], https://www.medicines.org.uk/emc/files/pil.8988.pdf
  3. Ciplamed; Accessed on 13th  June 2023; https://ciplamed-library.com/content/alfusin-d-tablets
  4. Package leaflet: Information for the user -Xatral 10mg tablets. www.hpra.ie. [Revised on Dec 2019],  [ Accessed on 13th  June 2023],https://www.hpra.ie/img/uploaded/swedocuments/2205503.PPA0465_138_002.856a0b73-285a-41e8-9b98-7a162579cd59.000001Xatral%20PIL.180515.pdf
  5. Package leaflet: Information for the user -Xatral 10mg tablets. www.hpra.ie. [Revised on Feb 2019],  [ Accessed on 13th  June 2023],https://www.hpra.ie/img/uploaded/swedocuments/b9581434-1b99-4640-806c-e9dd8a3531dc.pdf
  6. KD Tripathi, Essentials of Medical Pharmacology, Antiadrenergic Drugs (Adrenergic Receptor Antagonists) and Drugs for Glaucoma, 7th edition, 2013, 142.
  7. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Androgens, 12th edition, 2011, 1205.

Disclaimer

The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.