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Alfacalcidol
This page provides concise information about the drug alfacalcidol, including its indications, dosage and administration, mechanism of action, related brands with strength, warnings, and common side effects.
Background and Date of Approval
Alfacalcidol is a vitamin supplement drug approved by the U.S. Food and Drug Administration in 1978 for the treatment of osteodystrophy, which refers to changes in bone structure caused by kidney failure.
Mechanism of Action of Alfacalcidol
Alfacalcidol functions by improving calcium absorption from the intestines and facilitating the reabsorption of calcium by the kidneys. Additionally, it aids in regulating the release of parathyroid hormone (PTH), a crucial factor in maintaining calcium levels in the body.
Uses of Alfacalcidol
Alfacalcidol is used to address diverse conditions requiring adjustments in calcium levels within the body. It is primarily employed in the treatment of osteodystrophy (alterations in bone structure resulting from kidney failure), the management of hyperparathyroidism (excessive calcium in the blood due to overactive parathyroid glands) or hypoparathyroidism (insufficient calcium in the blood due to underactive parathyroid glands). Additionally, it is utilized in the treatment of hypocalcemia (low levels of calcium in the blood) in newborn infants, as well as for addressing rickets or osteomalacia (bone deformities due to a lack of calcium).
Alfacalcidol Drug administaration and Dosage available
Take Alfacalcidol as directed by your physician. Do not crush, chew, or open the medicine. Your physician will determine the appropriate dosage and duration based on factors such as age, body weight, and the specific disease condition. Only discontinue the capsule if your doctor recommends it.
Warnings, Precautions and Side Effects of Alfacalcidol
Warnings
This medication is not suitable for individuals with a known hypersensitivity or allergy to it or its components. Those with kidney issues, including kidney stones, may necessitate special monitoring and dosage adjustments. Your doctor must assess your kidney function and determine the appropriate dose. If you have hypercalcemia, characterized by high calcium levels in your blood, Alfacalcidol should not be taken, as it could exacerbate the condition by further increasing calcium levels.
Precautions
Your doctor may prescribe additional medications in conjunction with Alfacalcidol, such as a phosphate-binding agent to regulate phosphate levels or a calcium supplement to maintain appropriate calcium levels in your blood. This medication can impact calcium and phosphate levels in the blood, and your doctor may need to adjust your dose if you exhibit signs of elevated calcium or phosphate. Regular blood tests are typically conducted to monitor these levels, especially in children, individuals with kidney issues, or those on a high dose of the medication. If you are pregnant, suspect pregnancy, or plan to become pregnant, inform your doctor. It is unknown if this medication passes into breast milk, so consult your doctor before breastfeeding.
Side Effects
Common side effects during Alfacalcidol treatment include abdominal pain, headache, dizziness, confusion, and hives. Serious side effects may include allergic reactions, difficulty breathing, swelling of the face or throat, and severe rash.
Word Of Advice
Inform your doctor about all recently taken medications, including herbs and supplements, before starting Alfacalcidol. If you miss a dose for an entire day, take your usual dose the next day, but do not double-dose. Dispose of unused or expired medicines. Keep medications out of reach of children and pets. Avoid storing these medicines in damp locations, such as bathrooms, cabinets, or near kitchen sinks.
Frequently Asked Question
Taking excessive amounts of Alfacalcidol can lead to vitamin D toxicity, which can cause symptoms
such as high blood calcium levels, nausea, vomiting, increased thirst, and confusion. It’s important to
take this drug as prescribed and follow the recommended dosage to avoid the risk of overdose.
Yes, Alfacalcidol can interact with certain medications, including thiazide diuretics, calcium
supplements, and certain antacids. It’s important to inform your doctor about all the medications,
supplements, and herbal products you are taking to avoid serious interactions.
Common side effects of Alfacalcidol may include increased calcium levels (hypercalcemia),
increased phosphorus levels (hyperphosphatemia), headache, dizziness, nausea, vomiting, and
stomach discomfort. Inform your physician if you experience any severe side effects.
The dosage and administration of Alfacalcidol will vary depending on the individual and the specific
condition being treated. It is taken orally as a capsule or liquid, with or without food, as directed by
your physician. It’s important to follow the prescribed dosage and schedule closely.
Alfacalcidol works by promoting the absorption of calcium and phosphate from the intestines,
enhancing their reabsorption from the kidneys, and aiding in the regulation of calcium metabolism.
References
- Neon Healthcare Limited, Electronic medicines compendium (EMC), [Revised on Feb 2022] [ Accessed on 14th July 2023], https://www.medicines.org.uk/emc/files/pil.12653.pdf
- Sandoz Canada Inc, Sandoz Alfacalcidol Product Monograph., [Revised on Dec 2022] [ Accessed on 14th July 2023], https://www.sandoz.ca/sites/www.sandoz.ca/files/Sandoz_Alfacalcidol_Product_Monograph.pdf
- Aristo Pharma GmbH, NeoFalcon LifeScience, [ Accessed on 14th July 2023] https://file.wuxuwang.com/hma/DK_H_2674_001_FinalPL.pdf
Disclaimer
The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.