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Baricitinib
This page contains brief details about the drug baricitinib, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
Baricitinib was initially approved by the United States Food and Drug Administration (FDA) on May 31, 2018.
Mechanism of Action of Baricitinib
Baricitinib is a Janus kinase (JAK) inhibitor, targeting JAK1 and JAK2 enzymes. These enzymes are integral to intracellular signaling pathways involved in immune responses and inflammation. By inhibiting JAK1 and JAK2, it interferes with transmitting signals that contribute to the activation of immune cells and the production of inflammatory molecules. This modulation of signaling pathways leads to a dampened immune response and reduced inflammation, effectively managing autoimmune conditions like rheumatoid arthritis.
AVAILABLE BRANDS
Uses of Baricitinib
Baricitinib is mainly prescribed to address moderate to severe rheumatoid arthritis in adults who have not responded sufficiently to traditional disease-modifying antirheumatic drugs (DMARDs). Its primary role is to reduce inflammation and manage autoimmune conditions. Moreover, it shows promise for treating various other autoimmune disorders and inflammatory conditions.
Baricitinib Drug administaration and Dosage available
Baricitinib is commonly taken orally, typically in tablet form, ingested by mouth. It’s conveniently available as an oral tablet for ease of use. Your healthcare provider will prescribe the appropriate dosage and frequency of administration tailored to your medical condition and personal requirements.
Warnings, Precautions and Side Effects of Baricitinib
Warnings
Baricitinib carries the potential to elevate the risk of severe infections such as tuberculosis, bacterial, fungal, and viral infections. Additionally, there’s a heightened possibility of blood clots, potentially leading to conditions like deep vein thrombosis or pulmonary embolism. Its use may also be linked to an increased risk of certain cancers, including lymphoma. Gastrointestinal perforations are a concern, especially in individuals with diverticulitis or gastrointestinal problems. Baricitinib can affect liver enzymes and may be associated with mood changes and depression.
Precautions
Before starting Baricitinib, screen for tuberculosis (TB), and treat individuals with latent TB prior to initiating treatment. Individuals with active infections should refrain from using Baricitinib. Close monitoring is necessary for individuals at higher risk of blood clots, and regular cancer screenings are advisable. It’s important to regularly monitor liver function and avoid live vaccines while taking Baricitinib due to potential reduced vaccine efficacy. Additionally, mental health should be closely monitored.
Side Effects
Typical side effects of Baricitinib encompass upper respiratory tract infections, headaches, elevated liver enzymes, heightened blood pressure, fluctuations in blood cell counts, and increased cholesterol levels. Serious adverse effects may involve heightened susceptibility to severe infections, risk of blood clots, potential for malignancies, gastrointestinal perforations, liver abnormalities, and reactivation of hepatitis B. Additional concerns include cardiovascular risks, exacerbation of interstitial lung disease, alterations in mental health, heightened risk of skin cancer, potential aggravation of diabetes, and implications for surgical procedures.
Word Of Advice
Before initiating Baricitinib treatment, it’s essential to discuss your cardiovascular health with your healthcare provider. Close monitoring of blood sugar levels is advised, and adjustments to diabetes management should be discussed with your healthcare provider if necessary. Potential gastrointestinal issues, including gastrointestinal perforations and liver abnormalities, should be noted, with close monitoring of liver enzymes, cholesterol levels, and blood pressure. Screen for hepatitis B prior to starting treatment, and vaccination schedules may require adjustment. Pay attention to stomach and intestinal problems, plan surgeries accordingly, and be vigilant for cataracts and drug allergies. Exercise caution in individuals with a history of or risk factors for interstitial lung disease, as Baricitinib may exacerbate this condition. Consider the potential risk of lymphoma and other malignancies associated with this medication. Protect your skin from sun exposure and promptly report any skin changes to your healthcare provider. Regular eye check-ups are recommended as well.
Frequently Asked Question
Baricitinib may increase the risk of serious infections. Tuberculosis (TB) should be ruled out before starting treatment.
Yes, Baricitinib may increase the risk of blood clots, particularly in individuals at higher risk. Close monitoring is recommended.
The onset of improvement can vary. Some individuals may experience symptom relief within weeks, while others might take longer to respond.
No, following your healthcare provider’s instructions is important and not discontinuing Baricitinib without consulting them, even if your symptoms improve.