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ARSENIC TRIOXIDE
This page contains brief details about the drug arsenic trioxide, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
Arsenic Trioxide is an antineoplastic agent that belongs to the class of natural products. Initially, FDA approved it on September 25, 2000, for its medical use.
Mechanism of Action of Arsenic Trioxide
Arsenic trioxide impacts numerous signaling pathways, leading to alterations in cellular function. These effects culminate in the demise of cells, as well as the suppression of growth, division, and proliferation of cancerous cells.
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Uses of Arsenic Trioxide
Arsenic trioxide, administered intravenously, serves as an antineoplastic medication. It is prescribed for the treatment of newly diagnosed low to intermediate-risk acute promyelocytic leukemia (a form of bone cancer characterized by an accumulation of immature blood cells in the bone marrow), often in combination with tretinoin. Additionally, it is indicated for patients with acute promyelocytic leukemia (APL) who have not responded to alternative treatments or whose condition has deteriorated despite prior medication regimens.
Arsenic Trioxide Drug administaration and Dosage available
The administration of this medication should be carried out solely by healthcare professionals proficient in cancer chemotherapy. Your doctor will prescribe the appropriate dosage, frequency, and duration of treatment tailored to your specific cancer type and disease severity. Arsenic trioxide is provided in injectable form and administered intravenously as a drip (infusion) over 1 to 2 hours. Throughout the infusion process, you will be closely monitored for any adverse reactions.
Warnings, Precautions and Side Effects of Abciximab
Warnings
The medication is designed to induce liver toxicity. Regular monitoring of liver function tests is essential, and adjustments to dosage may be required if you have liver disorders. Arsenic trioxide is not advisable during pregnancy and breastfeeding due to potential harm to the fetus. Additionally, as arsenic trioxide is a human carcinogen, monitoring for secondary cancers is advised. It’s crucial to inform your physician promptly if you experience symptoms such as fever, sudden weight gain, dizziness/lightheadedness, shortness of breath, or any signs indicating fluid accumulation in the lungs, heart, or chest.
Precautions
Notify your physician regarding any existing heart disease, kidney disease, liver disease, or vitamin deficiencies. Inform your physician if you have allergies to arsenic trioxide or any of its components. If you are pregnant, breastfeeding, or planning pregnancy, it’s important to discuss this with your physician. During treatment, employ effective contraception to avoid pregnancy. Female patients capable of reproduction should utilize effective contraception throughout therapy and for a minimum of 6 months post-treatment. Male patients with female partners capable of reproduction should also employ effective contraception for at least 3 months following the completion of therapy.
Side Effects
Common side effects may include facial and bodily swelling, lowered blood pressure, itchy skin, elevated blood sugar levels, abdominal discomfort, constipation or diarrhea, nausea, vomiting, bone and muscle pain, dizziness, headaches, insomnia, throat irritation, loss of appetite, nosebleeds, coughing, difficulty breathing, fever, and fatigue. Additionally, serious side effects may include anemia, alterations in heart rate, liver toxicity, hypersensitivity reactions, infections leading to sepsis, kidney issues, and pneumonia.
Word Of Advice
Keep this medication stored at temperatures between 2–8ºC, ensuring it does not freeze. Store it in a location inaccessible to children and pets. In the event of a missed injection on the scheduled day, promptly notify your physician or healthcare provider to reschedule the dose. Arsenic trioxide is not advised for use in individuals below 18 years of age.
Frequently Asked Question
Arsenic trioxide is unsafe to use in pregnancy and breastfeeding. Avoid pregnancy during the treatment. Use effective contraceptives during the treatment for at at least 6 months (females) or 3 months (males) after receiving the final dose.
The dose and duration of the treatment will be decided by your doctor based on your disease condition, severity, and other factors. Do not stop receiving the treatment without consulting your physician.
Inform your doctor if you have liver or kidney problems, allergies, and other medications that you take, including over-the-counter medicines, vitamin supplements, and herbal products.
Yes, consuming alcohol regularly during the treatment with arsenic trioxide can make you more prone to vitamin B12 deficiency. Inform your doctor if you are consuming alcohol daily.
Arsenic trioxide does not cause weight gain. If you see any sudden changes in your weight, inform your physician immediately.
Disclaimer
The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.