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Introduction to Actilyse 50mg Injection
Actilyse 50mg injection contains Alteplase as its active component, also known as recombinant tissue plasminogen activator (rt-PA). It is utilized to treat specific medical conditions involving blood clots and acts as a thrombolytic agent, aiding in the breakdown of blood clots. This medication is frequently employed in the management of acute ischemic strokes, where a blood clot obstructs blood flow to the brain, potentially causing brain damage. Administering Alteplase within a specific time frame after the onset of stroke symptoms aims to restore blood flow to the affected brain tissue, reducing the risk of long-term disability. By reinstating blood flow to the affected brain area, Actilyse 50mg injection can minimize the extent of brain tissue damage caused by the stroke, leading to a reduction in long-term disability and an improved chance of recovery for stroke patients. However, like any medication, Actilyse can have side effects, with bleeding being a common occurrence, particularly in the brain or gastrointestinal tract. Prior to administration, doctors typically evaluate the patient’s medical history and consider any contraindications.
Individuals with a confirmed allergy or hypersensitivity to Actilyse 50mg injection or any of its components should refrain from receiving this medication. Patients who have experienced significant trauma (head trauma or internal injuries) within the past three months and are at an elevated risk of bleeding should also avoid this medication. Caution is recommended in individuals with severe liver or kidney impairment, as this medication is eliminated from the body through these organs. Additionally, the risk of bleeding complications may increase with advanced age, particularly in patients over 75.
Uses of Actilyse 50mg Injection
Actilyse 50mg injection is used to treat the following:
- Heart attack
- Acute ischemic stroke
- Acute massive pulmonary embolism (blood clots in the lung)
Therapeutic Effects of Actilyse 50mg Injection
Actilyse 50mg injection facilitates the conversion of the plasminogen enzyme into plasmin, aiding in the breakdown of fibrin found in blood clots. This mechanism contributes to the restoration of blood flow. Consequently, it is employed in the treatment of acute ischemic stroke, effectively dissolving clots and minimizing associated damage.
Interaction of Actilyse 50mg Injection with other drugs
Notify your doctor about all the medications you are taking, including prescribed drugs, over-the-counter medicines, nutritional or vitamin supplements, and herbal products. Some medications may interact with Actilyse 50mg injection, potentially reducing its effectiveness and causing undesirable side effects.
More Information about Actilyse 50mg Injection
- Store at room temperature, between 20°C to 25°C (68°F to 77°F).
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep away from children and pets.
How to consume Actilyse 50mg Injection
Actilyse 50mg injection is delivered intravenously (injection into a vein) under medical supervision. Your healthcare professional will establish the appropriate dosage and provide administration guidelines tailored to your condition and requirements.
Safety Advices for Actilyse 50mg Injection
Pregnancy
If a pregnant woman requires treatment with Actilyse 50mg injection, then they should consult a healthcare provider. They will weigh the potential benefits of resolving the critical situation against the potential risks to the developing fetus.
Breast Feeding
Liver
Using Actilyse 50mg injection in patients with liver impairment requires consultation with a qualified healthcare professional, who will consider the patient’s medical history, liver function, and overall risk profile.
Alcohol
Regarding the safety of Actilyse 50mg injection and alcohol consumption, it is generally recommended to avoid consuming alcohol while taking it. Alcohol can have various effects on the body, potentially affecting the cardiovascular system and increasing the risk of adverse reactions.
Driving
Actilyse 50mg injection can cause certain side effects that may impair your driving ability. These side effects can include dizziness, lightheadedness, blurred vision, and transient changes in heart rhythm. These effects can interfere with your concentration, alertness, and coordination, making driving potentially unsafe.
Side Effects of Actilyse 50mg Injection
Actilyse 50mg injection cause some side effects like all medications, although not everyone will experience them.
Serious:
- Bleeding
- Allergic reactions
- Hypotension (low blood pressure)
- Cardiac arrhythmias
- Hypersensitivity reactions
Common:
- Low blood pressure
- Chest pain
- Fluid on the lungs
- Bleeding of the damaged blood vessel
- Bleeding at the injection site
Word of Advice
Always seek advice from a healthcare professional before initiating or modifying your medication regimen, especially with Actilyse 50mg injection. Inform your doctor of any history of bleeding disorders, recent surgeries or trauma, gastrointestinal bleeding, or other conditions that may heighten the risk of bleeding. Vigilant monitoring of patients is essential throughout the treatment period to promptly identify any instances of bleeding or adverse reactions. This medication should be administered in a hospital setting equipped with emergency facilities, and immediate medical care must be accessible in case of complications. Pregnant and breastfeeding women should consult a doctor before commencing treatment. Advanced age, particularly in patients over 75, can elevate the risk of bleeding complications, necessitating dosage adjustments in elderly patients.
FAQs
Q 1. Is Actilyse 50mg injection effective in all cases of stroke or blood clots?
Actilyse 50mg injection is most effective when administered within the recommended time window and in specific cases of acute ischemic stroke, pulmonary embolism, or acute myocardial infarction. Its use must be carefully evaluated on a case-by-case basis by qualified healthcare professionals.
Q 2. Are there any contraindications for using Actilyse 50mg injection?
Actilyse 50mg injection is contraindicated in certain conditions, such as active bleeding, recent major surgery, intracranial hemorrhage, known hypersensitivity to it, and other situations with an increased risk of bleeding.
Q 3. Are there any specific tests required before administering Actilyse 50mg injection?
Before administering Actilyse 50mg injection, healthcare professionals typically perform brain imaging (CT or MRI) to rule out hemorrhagic stroke, which is a contraindication for this medication use. They may also conduct blood tests to assess coagulation parameters and ensure that the patient meets the necessary criteria for treatment.
Q 4. Is there a reversal agent for Actilyse 50mg injection if bleeding occurs.
There is no specific reversal agent for Actilyse 50mg injection. In case of severe bleeding complications, healthcare professionals may use supportive measures, blood products, or other interventions to manage bleeding. Close monitoring and immediate medical attention are essential to address any adverse events promptly.
Fact Box of Actilyse 50mg Injection
Molecule name: Alteplase
Pharmacological class:Tissue plasminogen activator (tPA)
Therapeutic class: Thrombolytic agent
Indications:
1. Heart attack
2. Acute ischemic stroke
3. Acute massive pulmonary embolism
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