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Alpha Ketoanalogue

This page provides concise information about the drug alpha-ketoanalogue, including its indications, dosage and administration details, mechanism of action, related brands with strengths, warnings, and common side effects.

Background and Date of Approval

Alpha Ketoanalogue is a nutritional supplement prescribed to enhance the nutritional status of individuals with chronic kidney disease.

Mechanism of Action of Alpha Ketoanalogue

Alpha Ketoanalogue is a biological agent categorized as a nutritional supplement. Following administration, the ketoanalogues undergo transamination, incorporating nitrogen from certain non-essential amino acids. This process reduces urea formation, preventing the buildup of uremic toxins and thereby promoting kidney health.

AVAILABLE BRANDS

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Reketo Tablet
Rindz Pharma Pvt Ltd ₹275.00
Renchek Tablet
Intas Pharmaceuticals Ltd ₹399.00
Nefrogard Tablet
Centaur Pharmaceuticals Pvt Ltd ₹137.38
Renolog Tablet
LA RENON HEALTHCARE PVT LTD ₹374.00

Uses of Alpha Ketoanalogue

Alpha Ketoanalogue is formulated to prevent and address kidney damage in patients with chronic kidney disease whose glomerular filtration rate is below 25 ml per minute. It rectifies impaired protein metabolism resulting from low protein intake (less than 40g/day). By preserving nutritional status, it effectively delays disease progression and the initiation of dialysis treatment.

Alpha Ketoanalogue Drug administaration and Dosage available

Alpha ketoanalogue is accessible in powder, granule, and tablet forms. The dosage and frequency depend on body weight and glomerular filtration rate.

Warnings, Precautions and Side Effects of Alpha Ketoanalogue

Warnings

Throughout Alpha Ketoanalogue treatment, your doctor may routinely assess your serum calcium, serum phosphate, and other kidney parameters to avert potential serious complications. Inform your doctor if you have a diagnosis of hereditary phenylketonuria.

Precautions

There is insufficient information regarding the effects of Alpha Ketoanalogue in pregnant and breastfeeding women. It is advisable to exercise caution before using Alpha Ketoanalogue during pregnancy and breastfeeding.

Side Effects

Alpha Ketoanalogue is generally not linked to any severe side effects; however, hypercalcemia is the most prevalent side effect. Your healthcare provider will routinely monitor your serum calcium levels to detect hypercalcemia and may recommend reducing the intake of calcium and vitamin D sources.

Word Of Advice

Consume a diet rich in calories. Use Alpha Ketoanalogue only as directed by your healthcare provider.

Frequently Asked Question

Alpha Ketoanalogue is a nutritional supplement indicated to improve kidney health in patients diagnosed with chronic kidney disease by decreasing uremic toxins, reducing proteinuria, delaying the onset of dialysis treatment and improving metabolism.
While for women with reproductive potential subjected to Alpha Ketoanalogue, it is advised to discuss with your doctor regarding the effective birth control methods during the treatment. Also, to be continued for a minimum of 6 months after the treatment course completion as this medicine may impair fertility.
People who are hypersensitive to Alpha ketoanalogue or any of its excipients, those with high calcium levels in their blood and disturbed amino acid metabolism should not use Alpha ketoanalogue.
Avoid taking medicines like tetracycline, ciprofloxacin, norfloxacin, estramustine and medications containing iron and fluoride while on treatment with Alpha ketoanalogue.
Your physician will regularly monitor pure serum calcium levels and if there is a suspicion of hypercalcemia, you will be required to reduce the intake of calcium containing foods and Vitamin D.
Store Alpha Ketoanalogue at room temperature, away from the reach of children.

References

  1. Centor Pharma, [Revised on Jan 2021] [Accessed on 0th Aug 2022],https://www.centorpharma.com/downloads/2021/nephrology/NEFROGARD.pdf
  2. Wu C-H, Yang Y-W, Hung S-C, Kuo K-L, Wu K-D, Wu V-C, et al., (2017) Ketoanalogues supplementation decreases dialysis and mortality risk in patients with anemic advanced chronic kidney disease, PLoS ONE, 12(5): e0176847,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419544/pdf/pone.0176847.pdf
  3. Hospimax, [Accessed on 30th Aug 2022], http://www.hospimax.com/formulation/Pospondyl%20website%20data.pdf
  4. La Renon Healthcare Pvt Ltd., [Revised on 2019] [Accessed on 30th Aug 2022], https://www.larenon.com/wp-content/uploads/2019/03/IMPULOG.pdf

Disclaimer

The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.